ENSMUSG00000059498


Mus musculus

Features
Gene ID: ENSMUSG00000059498
  
Biological name :Fcgr3
  
Synonyms : Fcgr3 / Mus musculus Fc receptor, IgG, low affinity III (Fcgr3), transcript variant 2, mRNA.
  
Possible biological names infered from orthology : Fc fragment of IgG receptor IIa / Fc fragment of IgG receptor IIb / Fc fragment of IgG receptor IIc (gene/pseudogene) / FCGR2A / FCGR2B / FCGR2C / P12318 / P31994
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H3
Gene start: 171051174
Gene end: 171064935
  
Corresponding Affymetrix probe sets: 10360040 (MoGene1.0st)   1448620_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131938
Ensembl peptide - ENSMUSP00000133039
Ensembl peptide - ENSMUSP00000131836
NCBI entrez gene - 14131     See in Manteia.
MGI - MGI:95500
RefSeq - XM_006496661
RefSeq - NM_001356511
RefSeq - NM_010188
RefSeq - XM_006496658
RefSeq - XM_006496659
RefSeq - XM_006496660
RefSeq Peptide - NP_034318
RefSeq Peptide - NP_001343440
swissprot - E9PVR4
swissprot - E9PUV2
swissprot - A0A0B4J1M6
Ensembl - ENSMUSG00000059498
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FCGR2AENSG00000143226Homo sapiens
 FCGR2BENSG00000072694Homo sapiens
 FCGR2CENSG00000244682Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fcgr2b / P31994* / FCGR2A* / FCGR2C* / P12318* / Fc fragment of IgG receptor IIa* / Fc fragment of IgG receptor IIb* / Fc fragment of IgG receptor IIc (gene/pseudogene)*ENSMUSG0000002665669
Fcgr4 / A0A0B4J1G0 / Low affinity immunoglobulin gamma Fc region receptor IV / P08637* / FCGR3A* / FCGR3B* / O75015* / Fc fragment of IgG receptor IIIa* / Fc fragment of IgG receptor IIIb*ENSMUSG0000005908940
Fcgr1 / P26151 / High affinity immunoglobulin gamma Fc receptor I / Q92637* / FCGR1A* / FCGR1B* / P12314* / Fc fragment of IgG receptor Ib* / Fc fragment of IgG receptor Ia*ENSMUSG0000001594736
Fcrlb / Q5DRQ8 / Fc receptor-like B / Q6BAA4*ENSMUSG0000007052429
Fcer1a / P20489 / High affinity immunoglobulin epsilon receptor subunit alpha / P12319* / Fc fragment of IgE receptor Ia*ENSMUSG0000000533927
Fcrl5 / Q68SN8 / Fc receptor-like protein 5 / Q96RD9* / Fc receptor like 5*ENSMUSG0000004803122
Fcrla / Q920A9 / Fc receptor-like A / Q7L513*ENSMUSG0000003842119
FcrlsENSMUSG0000001585211
Fcrl6 / A1YIY0 / Fc receptor-like protein 6 ENSMUSG000000705049
Fcrl1 / Q96LA6* / Fc receptor like 1*ENSMUSG000000599943


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000217 abnormal white blood cell count "anomalies in the number of leukocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0002531 type I hypersensitivity reaction "a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0004771 increased anti-single stranded DNA antibody level "increase in the level of antibodies that recognize single stranded DNA" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0004796 increased anti-histone antibody level "elevated level of antibodies to histones present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0004828 decreased susceptibility to autoimmune hemolytic anemia "reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004829 increased anti-chromatin antibody level "increase in the level of antibodies that recognize chromatin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0004952 increased spleen weight "greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Sle21129P2/Ola/Sle21129P2/Ola
Genetic Background: B6.129S4-Fcgr2btm1Ttk

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005596 increased susceptibility to type I hypersensitvity reaction "greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Knt/Fcer1atm1Knt,Fcer2atm1Max/Fcer2atm1Max,Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ldlrtm1Her/Ldlrtm1Her,Scarb1tm1Dhu/Scarb1tm1Dhu
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6J

 MP:0005612 decreased susceptibility to type II hypersensitivity reaction "less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gli2tm1Alj/Gli2tm1Alj,Gli3Xt-J/Gli3Xt-J
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H/HeJ * Swiss Webster

 MP:0008765 decreased mast cell degranulation "reduction in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd28tm1Pjl/Cd28tm1Pjl
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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