ENSMUSG00000040751


Mus musculus

Features
Gene ID: ENSMUSG00000040751
  
Biological name :Lat2
  
Synonyms : Lat2 / Linker for activation of T-cells family member 2 / Q9JHL0
  
Possible biological names infered from orthology : Q9GZY6
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 134600022
Gene end: 134615025
  
Corresponding Affymetrix probe sets: 10534303 (MoGene1.0st)   1426169_a_at (Mouse Genome 430 2.0 Array)   1449606_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143998
Ensembl peptide - ENSMUSP00000143977
Ensembl peptide - ENSMUSP00000144457
Ensembl peptide - ENSMUSP00000144611
Ensembl peptide - ENSMUSP00000046900
Ensembl peptide - ENSMUSP00000076824
NCBI entrez gene - 56743     See in Manteia.
MGI - MGI:1926479
RefSeq - XM_006504456
RefSeq - NM_022964
RefSeq - XM_006504450
RefSeq - XM_006504451
RefSeq - XM_006504452
RefSeq - XM_006504453
RefSeq - XM_006504455
RefSeq - NM_020044
RefSeq Peptide - NP_064428
RefSeq Peptide - NP_075253
swissprot - A0A0J9YVD5
swissprot - A0A0J9YV28
swissprot - Q9JHL0
swissprot - A0A0J9YU43
Ensembl - ENSMUSG00000040751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LAT2ENSGALG00000043302Gallus gallus
 LAT2ENSG00000086730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR031428  Linker for activation of T-cells family member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002764 immune response-regulating signaling pathway IEA
 biological_processGO:0019722 calcium-mediated signaling ISS
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0043303 mast cell degranulation IEA
 biological_processGO:0050853 B cell receptor signaling pathway ISS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0042629 mast cell granule IEA
 cellular_componentGO:0045121 membrane raft ISS
 molecular_functionGO:0042169 SH2 domain binding ISS


Pathways (from Reactome)
Pathway description
Role of LAT2/NTAL/LAB on calcium mobilization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1.1Lov/Lattm1.1Lov,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lat2tm2Wz/Lat2tm2Wz,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: C57BL/6

Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Lattm1.1Lov/Lattm1.1Lov,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1.1Lov/Lattm1.1Lov,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001829 increased activated T cell number "greater than normal numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lat2tm2Wz/Lat2tm2Wz,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: C57BL/6

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Irs2tm1Mfw/Irs2tm1Mfw,Tg(Ins2-Irs2)13Mfw/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lattm1Les/Lattm1Les,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: C57BL/6

Allelic Composition: Lattm2Mal/Lattm2Mal,Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: involves: 129S2/SvPas

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lattm1.1Lov/Lattm1.1Lov,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

 MP:0003725 increased autoantibody level "elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

Allelic Composition: Lattm1.1Lov/Lattm1.1Lov,Lat2tm1Wz/Lat2tm1Wz
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lat2tm2Wz/Lat2tm2Wz,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lime1tm1Mal/Lime1tm1Mal,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: B6.Cg-Rag2tm1Fwa Lime1tm1Mal Tg(TcraH-Y,TcrbH-Y)1Pas

Allelic Composition: Lat2tm1Mal/Lat2tm1Mal
Genetic Background: B6.129S2-Lat2tm1Mal

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atp2b2dfw-2J/Atp2b2+,Cdh23ahl/Cdh23ahl
Genetic Background: involves: BALB/cByJ * MOLF

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lat2tm2Wz/Lat2tm2Wz,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: C57BL/6

 MP:0008049 increased memory T cell number "greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm3.1Wz/Lat2tm3.1Wz
Genetic Background: B6.Cg-Lat2tm3.1Wz

Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lat2tm1Wz/Lat2tm1Wz
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004508 Gab2 / GAB4* / Q2WGN9* / Q9UQC2* / GRB2 associated binding protein 2* / GRB2 associated binding protein family member 4*  / complex
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / reaction / complex
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000032462 Pik3cb / Q8BTI9 / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform / P42338* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta*  / reaction / complex
 ENSMUSG00000031834 O08908 / Pik3r2 / Phosphatidylinositol 3-kinase regulatory subunit beta / O00459* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2*  / complex / reaction
 ENSMUSG00000027665 P42337 / Pik3ca / Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform / P42336* / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / reaction / complex
 ENSMUSG00000041417 P26450 / Pik3r1 / phosphoinositide-3-kinase regulatory subunit 1 / P27986*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / reaction






 

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