ENSG00000117461


Homo sapiens

Features
Gene ID: ENSG00000117461
  
Biological name :PIK3R3
  
Synonyms : phosphoinositide-3-kinase regulatory subunit 3 / PIK3R3 / Q92569
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.1
Gene start: 46040140
Gene end: 46133036
  
Corresponding Affymetrix probe sets: 202743_at (Human Genome U133 Plus 2.0 Array)   211580_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000416647
Ensembl peptide - ENSP00000391431
Ensembl peptide - ENSP00000412546
Ensembl peptide - ENSP00000361075
Ensembl peptide - ENSP00000262741
NCBI entrez gene - 8503     See in Manteia.
OMIM - 606076
RefSeq - NM_001328651
RefSeq - NM_003629
RefSeq - XM_017002614
RefSeq - NM_001114172
RefSeq - NM_001303428
RefSeq - NM_001303429
RefSeq - NM_001328648
RefSeq - NM_001328649
RefSeq - NM_001328650
RefSeq Peptide - NP_001107644
RefSeq Peptide - NP_001290358
RefSeq Peptide - NP_001315577
RefSeq Peptide - NP_001315578
RefSeq Peptide - NP_001315579
RefSeq Peptide - NP_001315580
RefSeq Peptide - NP_003620
RefSeq Peptide - NP_001290357
swissprot - Q92569
swissprot - Q5T4P3
Ensembl - ENSG00000117461
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pik3r3bENSDARG00000034409Danio rerio
 ENSGALG00000010335Gallus gallus
 Pik3r3ENSMUSG00000028698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AL358075.4ENSG0000027813993
P27986 / PIK3R1 / phosphoinositide-3-kinase regulatory subunit 1ENSG0000014567573
O00459 / PIK3R2 / phosphoinositide-3-kinase regulatory subunit 2ENSG0000010564767
AC007192.1ENSG0000026817367


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001720  PI3K p85/p55 subunit
 IPR032498  PI3K p85 subunit, inter-SH2 domain
 IPR035020  PI3K p85 subunit, C-terminal SH2 domain
 IPR035022  PI3K p85 subunit, N-terminal SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006661 phosphatidylinositol biosynthetic process TAS
 biological_processGO:0008286 insulin receptor signaling pathway TAS
 biological_processGO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus ISS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IBA
 molecular_functionGO:0001784 phosphotyrosine residue binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016303 1-phosphatidylinositol-3-kinase activity TAS
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Constitutive Signaling by Aberrant PI3K in Cancer
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121879 P42336 / PIK3CA / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha  / complex
 ENSG00000051382 P42338 / PIK3CB / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta  / complex
 ENSG00000171608 O00329 / PIK3CD / phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta  / complex






 

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