ENSGALG00000025950


Gallus gallus

Features
Gene ID: ENSGALG00000025950
  
Biological name :PRKCA
  
Synonyms : PRKCA / protein kinase C alpha
  
Possible biological names infered from orthology : P17252
  
Species: Gallus gallus
  
Chr. number: 18
Strand: -1
Band:
Gene start: 7389079
Gene end: 7502399
  
Corresponding Affymetrix probe sets: Gga.14549.1.S1_at (Chicken Array)   Gga.18321.1.A1_at (Chicken Array)   Gga.18321.1.S1_at (Chicken Array)   GgaAffx.20127.1.S1_at (Chicken Array)   GgaAffx.20127.1.S1_s_at (Chicken Array)   GgaAffx.2458.1.S1_at (Chicken Array)   GgaAffx.26067.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000041561
Ensembl peptide - ENSGALP00000051696
NCBI entrez gene - 417430     See in Manteia.
RefSeq - XM_004946229
RefSeq - NM_001012804
RefSeq Peptide - NP_001012822
swissprot - Q5F3X1
swissprot - R4GHL2
Ensembl - ENSGALG00000025950
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcaENSDARG00000115657Danio rerio
 PRKCAENSDARG00000099841Danio rerio
 PRKCAENSG00000154229Homo sapiens
 PrkcaENSMUSG00000050965Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794378
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000044
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497041
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201640
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188939
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936432
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127031
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162027
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408126
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357025
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397124
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002159 desmosome assembly IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0010467 gene expression IMP
 biological_processGO:0010595 positive regulation of endothelial cell migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035408 histone H3-T6 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043536 positive regulation of blood vessel endothelial cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0070459 prolactin secretion IMP
 biological_processGO:0070555 response to interleukin-1 IEA
 biological_processGO:0090330 regulation of platelet aggregation IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0035403 histone kinase activity (H3-T6 specific) IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Calmodulin induced events
Disinhibition of SNARE formation
SHC1 events in ERBB2 signaling
Signaling by SCF-KIT
Regulation of KIT signaling
EGFR Transactivation by Gastrin
Syndecan interactions
Acetylcholine regulates insulin secretion
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+
RET signaling
ROBO receptors bind AKAP5


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000002555 RET / ret proto-oncogene / P07949* / P35546* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-membrane anchored RET cadherin 120 kDa fragment*  / reaction / complex
 ENSGALG00000007620 GFRA3 / GDNF family receptor alpha 3 / O35118* / O60609*  / complex / reaction
 ENSGALG00000038634 KIT / Q08156 / Mast/stem cell growth factor receptor Kit / P05532* / P10721* / KIT proto-oncogene receptor tyrosine kinase*  / complex / reaction
 ENSGALG00000003716 GDNF / glial cell derived neurotrophic factor / P39905* / P48540* / Mus musculus glial cell line derived neurotrophic factor (Gdnf), transcript variant 3, mRNA.*  / complex / reaction
 ENSGALG00000009173 GFRA1 / O13156 / GDNF family receptor alpha-1 / P56159* / P97785*  / reaction / complex
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000021647 NRTN / neurturin / P97463* / Q99748*  / complex / reaction
 ENSGALG00000039775 SHC1 / SHC adaptor protein 1 / P29353* / P98083* / SHC-transforming protein 1 *  / reaction
 ENSGALG00000037726 MARCKS / myristoylated alanine-rich C-kinase substrate / P26645* / P29966* / myristoylated alanine rich protein kinase C substrate*  / reaction






 

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