ENSGALG00000023541


Gallus gallus

Features
Gene ID: ENSGALG00000023541
  
Biological name :SPHK1
  
Synonyms : sphingosine kinase 1 / SPHK1
  
Possible biological names infered from orthology : Q8CI15 / Q9NYA1
  
Species: Gallus gallus
  
Chr. number: 18
Strand: -1
Band:
Gene start: 4470026
Gene end: 4477538
  
Corresponding Affymetrix probe sets: GgaAffx.584.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000046487
Ensembl peptide - ENSGALP00000038332
NCBI entrez gene - 427803     See in Manteia.
RefSeq - XM_015295300
RefSeq - XM_004946119
swissprot - F1NN46
swissprot - A0A1D5P1F1
Ensembl - ENSGALG00000023541
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPHK1ENSG00000176170Homo sapiens
 Sphk1ENSMUSG00000061878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CERKL / ceramide kinase like / Q49MI3*ENSGALG0000000891018
CERK / ceramide kinase / Q8K4Q7* / Q8TCT0*ENSGALG0000001939717
AGK / acylglycerol kinase / Q53H12* / Q9ESW4* / Acylglycerol kinase, mitochondrial *ENSGALG0000001287013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0006670 sphingosine metabolic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IEA
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032651 regulation of interleukin-1 beta production IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046512 sphingosine biosynthetic process IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008481 sphinganine kinase activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0017050 D-erythro-sphingosine kinase activity IEA
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Association of TriC/CCT with target proteins during biosynthesis
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001270 PRKCZ / protein kinase C zeta / Q02956* / Q05513*  / reaction
 ENSGALG00000002016 PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*  / reaction
 ENSGALG00000030943 KRAS / KRAS proto-oncogene, GTPase / P01116* / P32883* / GTPase KRas GTPase KRas, N-terminally processed*  / reaction
 ENSGALG00000017706 RASA1* / P20936* / RAS p21 protein activator 1*  / reaction
 ENSGALG00000029260 H-RAS / P08642 / GTPase HRas GTPase HRas, N-terminally processed / HRAS* / Q61411* / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSGALG00000025950 PRKCA / protein kinase C alpha / P17252*  / reaction
 ENSGALG00000037943 PRKCB / protein kinase C beta / P05771* / P68404*  / reaction






 

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