ENSGALG00000037943


Gallus gallus

Features
Gene ID: ENSGALG00000037943
  
Biological name :PRKCB
  
Synonyms : PRKCB / protein kinase C beta
  
Possible biological names infered from orthology : P05771 / P68404
  
Species: Gallus gallus
  
Chr. number: 14
Strand: 1
Band:
Gene start: 6697241
Gene end: 6772052
  
Corresponding Affymetrix probe sets: Gga.6964.1.S1_at (Chicken Array)   GgaAffx.20120.1.S1_s_at (Chicken Array)   GgaAffx.26700.1.S1_s_at (Chicken Array)   GgaAffx.26700.3.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050632
Ensembl peptide - ENSGALP00000056743
Ensembl peptide - ENSGALP00000055990
NCBI entrez gene - 416567     See in Manteia.
RefSeq - XM_015294480
RefSeq - XM_015294481
swissprot - A0A1D5PUY5
swissprot - A0A1D5PSV1
swissprot - A0A1D5PCZ1
Ensembl - ENSGALG00000037943
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcbaENSDARG00000008723Danio rerio
 prkcbbENSDARG00000022254Danio rerio
 PRKCBENSG00000166501Homo sapiens
 PrkcbENSMUSG00000052889Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595079
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000044
PRKCD / protein kinase C delta type / P28867* / Q05655* / protein kinase C delta*ENSGALG0000000201641
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497041
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188940
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936431
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127031
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408127
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162027
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357025
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397124
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014375  Protein kinase C, alpha/beta/gamma types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0010829 negative regulation of glucose transmembrane transport IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IMP
 biological_processGO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0050853 B cell receptor signaling pathway IMP
 biological_processGO:0050861 positive regulation of B cell receptor signaling pathway IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0071322 cellular response to carbohydrate stimulus IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IMP
 molecular_functionGO:0005246 calcium channel regulator activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Disinhibition of SNARE formation
Activation of NF-kappaB in B cells
Trafficking of GluR2-containing AMPA receptors
Depolymerisation of the Nuclear Lamina
VEGFR2 mediated cell proliferation
Response to elevated platelet cytosolic Ca2+


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction






 

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