ENSGALG00000002016


Gallus gallus

Features
Gene ID: ENSGALG00000002016
  
Biological name :PRKCD
  
Synonyms : PRKCD / protein kinase C delta type
  
Possible biological names infered from orthology : P28867 / protein kinase C delta / Q05655
  
Species: Gallus gallus
  
Chr. number: 12
Strand: 1
Band:
Gene start: 1327662
Gene end: 1390974
  
Corresponding Affymetrix probe sets: GgaAffx.1340.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000035514
Ensembl peptide - ENSGALP00000057731
Ensembl peptide - ENSGALP00000045244
Ensembl peptide - ENSGALP00000003132
NCBI entrez gene - 415905     See in Manteia.
RefSeq - XM_015292765
RefSeq - XM_015292767
RefSeq - XM_015292766
RefSeq - NM_001006133
RefSeq Peptide - NP_001006133
swissprot - E1C5S5
swissprot - F1P3G1
swissprot - A0A1D5PXN4
Ensembl - ENSGALG00000002016
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkcdaENSDARG00000009208Danio rerio
 prkcdbENSDARG00000070651Danio rerio
 PRKCDENSG00000163932Homo sapiens
 PrkcdENSMUSG00000021948Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRKCQ / protein kinase C theta / Q02111* / Q04759*ENSGALG0000003497064
PRKCH / protein kinase C eta / P23298* / P24723*ENSGALG0000001188941
PRKCB / protein kinase C beta / P05771* / P68404*ENSGALG0000003794340
PRKCE / protein kinase C epsilon / P16054* / Q02156*ENSGALG0000001000040
PRKCA / protein kinase C alpha / P17252*ENSGALG0000002595039
PRKCZ / protein kinase C zeta / Q02956* / Q05513*ENSGALG0000000127029
PRKCI / protein kinase C iota type / P41743* / Q62074* / protein kinase C iota*ENSGALG0000000936428
AKT3 / AKT serine/threonine kinase 3 / Q9WUA6* / Q9Y243* / RAC-gamma serine/threonine-protein kinase *ENSGALG0000003408126
AKT1 / RAC-alpha serine/threonine-protein kinase / P31749* / P31750* / AKT serine/threonine kinase 1* / Mus musculus thymoma viral proto-onco 1 (Akt1), transcript variant 3, mRNA.*ENSGALG0000001162026
SGK3 / serum/glucocorticoid regulated kinase family member 3 / Q96BR1* / Q9ERE3* / serum/glucocorticoid regulated kinase 3*ENSGALG0000004357024
SGK1 / Q6U1I9 / Serine/threonine-protein kinase Sgk1 / Q9WVC6* / O00141* / serum/glucocorticoid regulated kinase 1*ENSGALG0000001397123
SGK2 / SGK2, serine/threonine kinase 2 / Q9HBY8* / Q9QZS5* / Serine/threonine-protein kinase Sgk2 *ENSGALG0000000353720


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR002219  Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR014376  Protein kinase C, delta/epsilon/eta/theta types
 IPR017441  Protein kinase, ATP binding site
 IPR017892  Protein kinase, C-terminal
 IPR020454  Diacylglycerol/phorbol-ester binding
 IPR027436  Protein kinase C, delta


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0016064 immunoglobulin mediated immune response IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016572 histone phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0023021 termination of signal transduction IEA
 biological_processGO:0030837 negative regulation of actin filament polymerization IEA
 biological_processGO:0032079 positive regulation of endodeoxyribonuclease activity IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0032613 interleukin-10 production IEA
 biological_processGO:0032615 interleukin-12 production IEA
 biological_processGO:0032930 positive regulation of superoxide anion generation IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042100 B cell proliferation IEA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0042307 positive regulation of protein import into nucleus IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0043407 negative regulation of MAP kinase activity IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0050732 negative regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051490 negative regulation of filopodium assembly IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0071447 cellular response to hydroperoxide IEA
 biological_processGO:0090331 negative regulation of platelet aggregation IEA
 biological_processGO:0090398 cellular senescence IEA
 biological_processGO:1900163 positive regulation of phospholipid scramblase activity IEA
 biological_processGO:1904385 cellular response to angiotensin IEA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process IEA
 biological_processGO:2000753 positive regulation of glucosylceramide catabolic process IEA
 biological_processGO:2000755 positive regulation of sphingomyelin catabolic process IEA
 biological_processGO:2001022 positive regulation of response to DNA damage stimulus IEA
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IEA
 cellular_componentGO:0005622 intracellular IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016363 nuclear matrix IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004697 protein kinase C activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008047 enzyme activator activity IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0043560 insulin receptor substrate binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
Neutrophil degranulation
Interferon gamma signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000023541 SPHK1 / sphingosine kinase 1 / Q8CI15* / Q9NYA1*  / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction
 ENSGALG00000009903 IFNG / P49708 / Interferon gamma / P01579* / P01580*  / reaction
 ENSGALG00000006418 PDPK1 / 3-phosphoinositide dependent protein kinase 1 / O15530* / Q9Z2A0*  / reaction
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction






 

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