ENSG00000176170


Homo sapiens

Features
Gene ID: ENSG00000176170
  
Biological name :SPHK1
  
Synonyms : Q9NYA1 / sphingosine kinase 1 / SPHK1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q25.1
Gene start: 76376584
Gene end: 76387860
  
Corresponding Affymetrix probe sets: 219257_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000468547
Ensembl peptide - ENSP00000466422
Ensembl peptide - ENSP00000468474
Ensembl peptide - ENSP00000313681
Ensembl peptide - ENSP00000376285
Ensembl peptide - ENSP00000440970
Ensembl peptide - ENSP00000465002
Ensembl peptide - ENSP00000465726
NCBI entrez gene - 8877     See in Manteia.
OMIM - 603730
RefSeq - XM_005257766
RefSeq - NM_001142601
RefSeq - NM_001142602
RefSeq - NM_021972
RefSeq - NM_182965
RefSeq Peptide - NP_001136073
RefSeq Peptide - NP_892010
RefSeq Peptide - NP_001136074
RefSeq Peptide - NP_001342068
RefSeq Peptide - NP_068807
swissprot - Q9NYA1
swissprot - K7EMA4
swissprot - Q53ZR5
swissprot - K7EJ32
Ensembl - ENSG00000176170
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SPHK1ENSGALG00000023541Gallus gallus
 Sphk1ENSMUSG00000061878Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPHK2 / Q9NRA0 / sphingosine kinase 2ENSG0000006317645
CERK / Q8TCT0 / ceramide kinaseENSG0000010042221
CERKL / Q49MI3 / ceramide kinase likeENSG0000018845219
AGK / Q53H12 / acylglycerol kinaseENSG0000000653015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006670 sphingosine metabolic process TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP
 biological_processGO:0010803 regulation of tumor necrosis factor-mediated signaling pathway IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0032651 regulation of interleukin-1 beta production IEA
 biological_processGO:0035556 intracellular signal transduction TAS
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0045766 positive regulation of angiogenesis IDA
 biological_processGO:0045931 positive regulation of mitotic cell cycle IDA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0046512 sphingosine biosynthetic process IMP
 biological_processGO:0046521 sphingoid catabolic process NAS
 biological_processGO:0046834 lipid phosphorylation IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IDA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding ISS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008481 sphinganine kinase activity IDA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017050 D-erythro-sphingosine kinase activity IDA
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IMP
 molecular_functionGO:0051721 protein phosphatase 2A binding IPI


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis
Association of TriC/CCT with target proteins during biosynthesis
VEGFR2 mediated cell proliferation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000166501 PRKCB / P05771 / protein kinase C beta  / reaction
 ENSG00000154229 PRKCA / P17252 / protein kinase C alpha  / reaction
 ENSG00000163932 PRKCD / Q05655 / protein kinase C delta  / reaction
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000145715 RASA1 / P20936 / RAS p21 protein activator 1  / reaction
 ENSG00000067606 PRKCZ / Q05513 / protein kinase C zeta  / reaction






 

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