ENSG00000100422


Homo sapiens

Features
Gene ID: ENSG00000100422
  
Biological name :CERK
  
Synonyms : ceramide kinase / CERK / Q8TCT0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.31
Gene start: 46684411
Gene end: 46738261
  
Corresponding Affymetrix probe sets: 218421_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400859
Ensembl peptide - ENSP00000216264
NCBI entrez gene - 64781     See in Manteia.
OMIM - 610307
RefSeq - XM_017028909
RefSeq - NM_022766
RefSeq Peptide - NP_073603
swissprot - A0A024R4U8
swissprot - Q8TCT0
swissprot - F8WFD8
Ensembl - ENSG00000100422
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cerkENSDARG00000069169Danio rerio
 CERKENSGALG00000019397Gallus gallus
 CerkENSMUSG00000035891Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CERKL / Q49MI3 / ceramide kinase likeENSG0000018845227
SPHK2 / Q9NRA0 / sphingosine kinase 2ENSG0000006317621
SPHK1 / Q9NYA1 / sphingosine kinase 1ENSG0000017617018
AGK / Q53H12 / acylglycerol kinaseENSG0000000653015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006672 ceramide metabolic process TAS
 biological_processGO:0006687 glycosphingolipid metabolic process TAS
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0001729 ceramide kinase activity TAS
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102773 dihydroceramide kinase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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