ENSMUSG00000035891


Mus musculus

Features
Gene ID: ENSMUSG00000035891
  
Biological name :Cerk
  
Synonyms : Ceramide kinase / Cerk / Q8K4Q7
  
Possible biological names infered from orthology : Q8TCT0
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E2
Gene start: 86139128
Gene end: 86186141
  
Corresponding Affymetrix probe sets: 10431266 (MoGene1.0st)   1434034_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038203
Ensembl peptide - ENSMUSP00000119472
NCBI entrez gene - 223753     See in Manteia.
MGI - MGI:2386052
RefSeq - XM_011245588
RefSeq - NM_145475
RefSeq - XM_006520831
RefSeq Peptide - NP_663450
swissprot - Q8K4Q7
swissprot - D3Z254
Ensembl - ENSMUSG00000035891
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cerkENSDARG00000069169Danio rerio
 CERKENSGALG00000019397Gallus gallus
 CERKENSG00000100422Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cerkl / ceramide kinase-like / Q49MI3*ENSMUSG0000007525627
Sphk2 / Q9JIA7 / sphingosine kinase 2 / Q9NRA0*ENSMUSG0000005734220
Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*ENSMUSG0000006187816
Agk / Q9ESW4 / Acylglycerol kinase, mitochondrial / Q53H12* / acylglycerol kinase*ENSMUSG0000002991615


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006672 ceramide metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0001729 ceramide kinase activity ISO
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0102773 dihydroceramide kinase activity IEA


Pathways (from Reactome)
Pathway description
Glycosphingolipid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0003867 increased defecation "increase in the production and excretion of feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ggt1dwg/Ggt1dwg
Genetic Background: STOCK Ggt1dwg/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0012232 abnormal ceramide level 
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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