ENSMUSG00000057342


Mus musculus

Features
Gene ID: ENSMUSG00000057342
  
Biological name :Sphk2
  
Synonyms : Q9JIA7 / sphingosine kinase 2 / Sphk2
  
Possible biological names infered from orthology : Q9NRA0
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B3
Gene start: 45709467
Gene end: 45718002
  
Corresponding Affymetrix probe sets: 10563362 (MoGene1.0st)   1417431_a_at (Mouse Genome 430 2.0 Array)   1426230_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072615
Ensembl peptide - ENSMUSP00000103366
Ensembl peptide - ENSMUSP00000147391
Ensembl peptide - ENSMUSP00000147787
NCBI entrez gene - 56632     See in Manteia.
MGI - MGI:1861380
RefSeq - XM_006541013
RefSeq - NM_001172561
RefSeq - NM_020011
RefSeq - NM_203280
RefSeq - XM_006541012
RefSeq Peptide - NP_064395
RefSeq Peptide - NP_975009
RefSeq Peptide - NP_001166032
swissprot - Q58E38
swissprot - Q9JIA7
swissprot - A0A1B0GS43
Ensembl - ENSMUSG00000057342
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sphk2ENSDARG00000069893Danio rerio
 SPHK2ENSG00000063176Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sphk1 / Q8CI15 / Sphingosine kinase 1 / Q9NYA1*ENSMUSG0000006187829
Cerk / Q8K4Q7 / Ceramide kinase / Q8TCT0*ENSMUSG0000003589118
Cerkl / ceramide kinase-like / Q49MI3*ENSMUSG0000007525616
Agk / Q9ESW4 / Acylglycerol kinase, mitochondrial / Q53H12* / acylglycerol kinase*ENSMUSG0000002991612


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006669 sphinganine-1-phosphate biosynthetic process NAS
 biological_processGO:0006670 sphingosine metabolic process IMP
 biological_processGO:0007420 brain development IGI
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0046512 sphingosine biosynthetic process ISO
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008481 sphinganine kinase activity NAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017050 D-erythro-sphingosine kinase activity IMP
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity ISO


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tsc1tm1Hin/Tsc1+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ndel1tm1Shr/Ndel1tm1Shr
Genetic Background: involves: 129S6/SvEvTac

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sulf1Gt(OST352220)Lex/Sulf1Gt(OST352220)Lex,Sulf2Gt(OST311938)Lex/Sulf2Gt(OST311938)Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc30a8tm1.1Geno/Slc30a8tm1.1Geno
Genetic Background: involves: 129/Sv * C57BL/6JRj

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006054 spinal hemorrhage "bleeding into the spine" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008053 abnormal NK cell differentiation "atypical production of or inability to produce the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008827 abnormal thymus cell ratio "deviation from the standard ratios of thymocyte subpopulations compared to control samples" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Sphk1tm1.1Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Rad54btm1Roka/Rad54btm1Roka
Genetic Background: involves: 129P2/OlaHsd

 MP:0009339 decreased splenocyte number "reduction in the expected number of cells of the spleen" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lyve1tm1.1(EGFP/cre)Cys/Lyve1+,Sphk1tm2Cgh/Sphk1tm2Cgh,Sphk2tm1.1Cgh/Sphk2tm1.1Cgh
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012261 increased hindbrain apoptosis "increase in the number of cells of the hindbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012503 increased midbrain apoptosis "increase in the number of cells of the midbrain undergoing programmed cell death" [MGI:anna]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012701 increased embryonic neuroepithelium apoptosis "increase in the number of cells of the embryonic neuroepithelium undergoing programmed cell death" [MGI:anna]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: S1pr1tm1Rlp/S1pr1tm1Rlp
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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