ENSG00000063176


Homo sapiens

Features
Gene ID: ENSG00000063176
  
Biological name :SPHK2
  
Synonyms : Q9NRA0 / sphingosine kinase 2 / SPHK2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.33
Gene start: 48619291
Gene end: 48630717
  
Corresponding Affymetrix probe sets: 209857_s_at (Human Genome U133 Plus 2.0 Array)   40273_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000470679
Ensembl peptide - ENSP00000470092
Ensembl peptide - ENSP00000471111
Ensembl peptide - ENSP00000472983
Ensembl peptide - ENSP00000471205
Ensembl peptide - ENSP00000471180
Ensembl peptide - ENSP00000245222
Ensembl peptide - ENSP00000341091
Ensembl peptide - ENSP00000410044
Ensembl peptide - ENSP00000469158
Ensembl peptide - ENSP00000469448
NCBI entrez gene - 56848     See in Manteia.
OMIM - 607092
RefSeq - XM_017027010
RefSeq - NM_001204158
RefSeq - NM_001204159
RefSeq - NM_001204160
RefSeq - NM_001243876
RefSeq - NM_020126
RefSeq - XM_006723292
RefSeq - XM_011527133
RefSeq - XM_011527134
RefSeq - XM_017027008
RefSeq - XM_017027009
RefSeq Peptide - NP_001191088
RefSeq Peptide - NP_001191087
RefSeq Peptide - NP_001191089
RefSeq Peptide - NP_001230805
RefSeq Peptide - NP_064511
swissprot - Q9NRA0
swissprot - M0QZP3
swissprot - M0R0E9
swissprot - M0R344
swissprot - M0QXX5
swissprot - A0A024QZH5
swissprot - E9PCV4
swissprot - E7ET12
swissprot - A0A075B7A1
Ensembl - ENSG00000063176
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sphk2ENSDARG00000069893Danio rerio
 Sphk2ENSMUSG00000057342Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SPHK1 / Q9NYA1 / sphingosine kinase 1ENSG0000017617033
CERK / Q8TCT0 / ceramide kinaseENSG0000010042217
CERKL / Q49MI3 / ceramide kinase likeENSG0000018845216
AGK / Q53H12 / acylglycerol kinaseENSG0000000653011


Protein motifs (from Interpro)
Interpro ID Name
 IPR001206  Diacylglycerol kinase, catalytic domain
 IPR016064  NAD kinase/diacylglycerol kinase-like domain superfamily
 IPR017438  Inorganic polyphosphate/ATP-NAD kinase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0003376 sphingosine-1-phosphate signaling pathway IEA
 biological_processGO:0006669 sphinganine-1-phosphate biosynthetic process NAS
 biological_processGO:0006670 sphingosine metabolic process IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030148 sphingolipid biosynthetic process TAS
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0046512 sphingosine biosynthetic process IMP
 biological_processGO:0046834 lipid phosphorylation IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003951 NAD+ kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008481 sphinganine kinase activity TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0017016 Ras GTPase binding NAS
 molecular_functionGO:0017050 D-erythro-sphingosine kinase activity TAS
 molecular_functionGO:0038036 sphingosine-1-phosphate receptor activity IMP


Pathways (from Reactome)
Pathway description
Sphingolipid de novo biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr