ENSGALG00000010915


Gallus gallus

Features
Gene ID: ENSGALG00000010915
  
Biological name :IL6
  
Synonyms : IL6 / Interleukin-6 / Q90YI0
  
Possible biological names infered from orthology : P05231 / P08505
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 30949385
Gene end: 30952079
  
Corresponding Affymetrix probe sets: Gga.15024.1.A1_at (Chicken Array)   Gga.15024.1.S1_at (Chicken Array)   Gga.2769.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000017738
NCBI entrez gene - 395337     See in Manteia.
RefSeq - NM_204628
RefSeq - XM_015281283
RefSeq Peptide - NP_989959
swissprot - Q90YI0
swissprot - D9ZYR9
Ensembl - ENSGALG00000010915
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL6ENSG00000136244Homo sapiens
 Il6ENSMUSG00000025746Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003574  Interleukin-6
 IPR009079  Four-helical cytokine-like, core
 IPR030473  Interleukin-6/GCSF/MGF, conserved site
 IPR030474  Interleukin-6/GCSF/MGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001781 neutrophil apoptotic process IEA
 biological_processGO:0002384 hepatic immune response IEA
 biological_processGO:0002675 positive regulation of acute inflammatory response IEA
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045727 positive regulation of translation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050871 positive regulation of B cell activation IEA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IEA
 biological_processGO:0070301 cellular response to hydrogen peroxide IEA
 biological_processGO:0070417 cellular response to cold IEP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005896 interleukin-6 receptor complex IEA
 molecular_functionGO:0005125 cytokine activity NAS
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK1 (ERK2) activation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / reaction / complex
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / reaction / complex
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / reaction / complex
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / complex / reaction
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction






 

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