ENSG00000136244


Homo sapiens

Features
Gene ID: ENSG00000136244
  
Biological name :IL6
  
Synonyms : IL6 / interleukin 6 / P05231
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p15.3
Gene start: 22725884
Gene end: 22732002
  
Corresponding Affymetrix probe sets: 205207_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258743
Ensembl peptide - ENSP00000384928
Ensembl peptide - ENSP00000405150
Ensembl peptide - ENSP00000385718
Ensembl peptide - ENSP00000385675
Ensembl peptide - ENSP00000385227
Ensembl peptide - ENSP00000385043
NCBI entrez gene - 3569     See in Manteia.
OMIM - 147620
RefSeq - XM_011515390
RefSeq - NM_000600
RefSeq - NM_001318095
RefSeq - XM_005249745
RefSeq Peptide - NP_000591
RefSeq Peptide - NP_001305024
swissprot - C9J5B0
swissprot - P05231
swissprot - B5MCZ3
swissprot - B5MC21
swissprot - B4DNV3
swissprot - B5MC14
swissprot - Q75MH2
Ensembl - ENSG00000136244
  
Related genetic diseases (OMIM): 266600 - {Crohn disease-associated growth failure}, 266600
  125853 - {Diabetes, susceptibility to}, 222100, 125853
  108010 - {Intracranial hemorrhage in brain cerebrovascular malformations, susceptibility to}, 108010
  148000 - {Kaposi sarcoma, susceptibility to}, 148000
  604302 - {Rheumatoid arthritis, systemic juvenile}, 604302
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL6ENSGALG00000010915Gallus gallus
 Il6ENSMUSG00000025746Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003574  Interleukin-6
 IPR009079  Four-helical cytokine-like, core
 IPR030473  Interleukin-6/GCSF/MGF, conserved site
 IPR030474  Interleukin-6/GCSF/MGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001781 neutrophil apoptotic process IDA
 biological_processGO:0002384 hepatic immune response TAS
 biological_processGO:0002446 neutrophil mediated immunity TAS
 biological_processGO:0002548 monocyte chemotaxis IC
 biological_processGO:0002675 positive regulation of acute inflammatory response IDA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis TAS
 biological_processGO:0006953 acute-phase response TAS
 biological_processGO:0006954 inflammatory response IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response IC
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IDA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0010888 negative regulation of lipid storage NAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0030168 platelet activation TAS
 biological_processGO:0031018 endocrine pancreas development ISS
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0032494 response to peptidoglycan NAS
 biological_processGO:0032722 positive regulation of chemokine production NAS
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0032966 negative regulation of collagen biosynthetic process IDA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IDA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0045079 negative regulation of chemokine biosynthetic process ISS
 biological_processGO:0045599 negative regulation of fat cell differentiation NAS
 biological_processGO:0045669 positive regulation of osteoblast differentiation TAS
 biological_processGO:0045727 positive regulation of translation IDA
 biological_processGO:0045765 regulation of angiogenesis IC
 biological_processGO:0045779 negative regulation of bone resorption ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IDA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium TAS
 biological_processGO:0050830 defense response to Gram-positive bacterium TAS
 biological_processGO:0050871 positive regulation of B cell activation IDA
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IDA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051384 response to glucocorticoid IDA
 biological_processGO:0051607 defense response to virus IDA
 biological_processGO:0070091 glucagon secretion ISS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IDA
 biological_processGO:0070301 cellular response to hydrogen peroxide IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IMP
 biological_processGO:0072540 T-helper 17 cell lineage commitment ISS
 biological_processGO:2000553 positive regulation of T-helper 2 cell cytokine production ISS
 biological_processGO:2000660 negative regulation of interleukin-1-mediated signaling pathway ISS
 biological_processGO:2000676 positive regulation of type B pancreatic cell apoptotic process TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005896 interleukin-6 receptor complex IDA
 molecular_functionGO:0005125 cytokine activity NAS
 molecular_functionGO:0005138 interleukin-6 receptor binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Senescence-Associated Secretory Phenotype (SASP)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000988 Skin rash 
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 HP:0001386 Joint swelling 
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 HP:0001701 Pericarditis 
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 HP:0001744 Splenomegaly "An abnormal enlargement of the spleen." [HPO:curators]
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 HP:0001945 Fever 
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 HP:0002027 Abdominal pain 
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 HP:0002202 Pleural effusion "The presence of an excessive amount of fluid in the pleural cavity." [HPO:curators]
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002716 Lymphadenopathy 
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 HP:0002829 Arthralgia 
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 HP:0002960 Autoimmune disease 
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 HP:0003565 Elevated erythrocyte sedimentation rate 
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 HP:0005681 Rheumatoid arthritis, juvenile 
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 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
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 HP:0012122 Anterior uveitis "Inflammation of the uveal tract in which the primary site of inflammation is the anterior chamber." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / reaction / complex
 ENSG00000136244 IL6 / P05231 / interleukin 6  / reaction / complex
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / reaction / complex
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / complex / reaction






 

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