ENSG00000160712


Homo sapiens

Features
Gene ID: ENSG00000160712
  
Biological name :IL6R
  
Synonyms : IL6R / interleukin 6 receptor / P08887
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q21.3
Gene start: 154405193
Gene end: 154469450
  
Corresponding Affymetrix probe sets: 205945_at (Human Genome U133 Plus 2.0 Array)   217489_s_at (Human Genome U133 Plus 2.0 Array)   226333_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000423036
Ensembl peptide - ENSP00000357470
Ensembl peptide - ENSP00000423184
Ensembl peptide - ENSP00000477739
Ensembl peptide - ENSP00000423668
Ensembl peptide - ENSP00000340589
NCBI entrez gene - 3570     See in Manteia.
OMIM - 147880
RefSeq - XM_017001201
RefSeq - NM_000565
RefSeq - NM_001206866
RefSeq - NM_181359
RefSeq - XM_005245139
RefSeq - XM_005245140
RefSeq - XM_006711298
RefSeq - XM_006711299
RefSeq - XM_017001199
RefSeq - XM_017001200
RefSeq Peptide - NP_001193795
RefSeq Peptide - NP_852004
RefSeq Peptide - NP_000556
swissprot - H0Y9B1
swissprot - D6R9R8
swissprot - P08887
swissprot - A0A087WTB5
swissprot - A0N0L5
swissprot - H0Y949
Ensembl - ENSG00000160712
  
Related genetic diseases (OMIM): 614689 - [Interleukin-6 receptor, soluble, serum level of, QTL], 614689
  614752 - [Interleukin 6, serum level of, QTL], 614752
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il6rENSDARG00000104474Danio rerio
 IL6RENSGALG00000030407Gallus gallus
 Il6raENSMUSG00000027947Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL11RA / Q14626 / interleukin 11 receptor subunit alphaENSG0000013707023
CNTFR / P26992 / ciliary neurotrophic factor receptorENSG0000012275621
EBI3 / Q14213 / Epstein-Barr virus induced 3ENSG0000010524612
AL162231.3ENSG000002587288


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002384 hepatic immune response TAS
 biological_processGO:0002548 monocyte chemotaxis IC
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis TAS
 biological_processGO:0006953 acute-phase response TAS
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IDA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IMP
 biological_processGO:0045669 positive regulation of osteoblast differentiation TAS
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IDA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium TAS
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IMP
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IMP
 biological_processGO:0097191 extrinsic apoptotic signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005896 interleukin-6 receptor complex IDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex IDA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity IMP
 molecular_functionGO:0004915 interleukin-6 receptor activity IDA
 molecular_functionGO:0005138 interleukin-6 receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019981 interleukin-6 binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0070119 ciliary neurotrophic factor binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK3 (ERK1) activation
MAPK1 (ERK2) activation
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / reaction / complex
 ENSG00000136244 IL6 / P05231 / interleukin 6  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000160712 IL6R / P08887 / interleukin 6 receptor  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000110395 CBL / P22681 / Cbl proto-oncogene  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000184557 SOCS3 / O14543 / suppressor of cytokine signaling 3  / reaction / complex






 

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