ENSG00000105246


Homo sapiens

Features
Gene ID: ENSG00000105246
  
Biological name :EBI3
  
Synonyms : EBI3 / Epstein-Barr virus induced 3 / Q14213
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 4229498
Gene end: 4237531
  
Corresponding Affymetrix probe sets: 219424_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000221847
NCBI entrez gene - 10148     See in Manteia.
OMIM - 605816
RefSeq - NM_005755
RefSeq - XM_011527619
RefSeq Peptide - NP_005746
swissprot - Q14213
Ensembl - ENSG00000105246
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ebi3ENSDARG00000053620Danio rerio
 Ebi3ENSMUSG00000003206Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNTFR / P26992 / ciliary neurotrophic factor receptorENSG0000012275630
IL11RA / Q14626 / interleukin 11 receptor subunit alphaENSG0000013707028
IL6R / P08887 / interleukin 6 receptorENSG0000016071224
AL162231.3ENSG0000025872810


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042088 T-helper 1 type immune response TAS
 biological_processGO:0042098 T cell proliferation IEA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process TAS
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation TAS
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IPI
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045523 interleukin-27 receptor binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127022 CANX / P27824 / calnexin  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / reaction / complex
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / complex






 

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