ENSG00000104998


Homo sapiens

Features
Gene ID: ENSG00000104998
  
Biological name :IL27RA
  
Synonyms : IL27RA / interleukin 27 receptor subunit alpha / Q6UWB1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.12
Gene start: 14031748
Gene end: 14053216
  
Corresponding Affymetrix probe sets: 205926_at (Human Genome U133 Plus 2.0 Array)   217702_at (Human Genome U133 Plus 2.0 Array)   222062_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000263379
NCBI entrez gene - 9466     See in Manteia.
OMIM - 605350
RefSeq - NM_004843
RefSeq Peptide - NP_004834
swissprot - Q6UWB1
Ensembl - ENSG00000104998
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il27raENSMUSG00000005465Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0048302 regulation of isotype switching to IgG isotypes IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0045509 interleukin-27 receptor activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex / reaction
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / reaction / complex
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / reaction / complex
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex






 

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