ENSMUSG00000005465


Mus musculus

Features
Gene ID: ENSMUSG00000005465
  
Biological name :Il27ra
  
Synonyms : Il27ra / Interleukin-27 receptor subunit alpha / O70394
  
Possible biological names infered from orthology : Q6UWB1
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C2
Gene start: 84030294
Gene end: 84042589
  
Corresponding Affymetrix probe sets: 10580061 (MoGene1.0st)   1449508_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005601
NCBI entrez gene - 50931     See in Manteia.
MGI - MGI:1355318
RefSeq - NM_016671
RefSeq - XM_011248437
RefSeq Peptide - NP_057880
swissprot - O70394
Ensembl - ENSMUSG00000005465
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL27RAENSG00000104998Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IMP
 biological_processGO:0002829 negative regulation of type 2 immune response IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0048302 regulation of isotype switching to IgG isotypes IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0070106 interleukin-27-mediated signaling pathway IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045509 interleukin-27 receptor activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dicer1tm1Bdh/Dicer1tm1Bdh,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004798 decreased anti-double stranded DNA antibody level "reduced level of antibodies to double stranded DNA present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0004822 decreased susceptibility to experimental autoimmune uveoretinitis "reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hsp90aa1Gt(S17-2G1)Sor/Hsp90aa1Gt(S17-2G1)Sor
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Bmpr2tm1Kmi/Bmpr2+,Btg2tm1Spo/Btg2tm1Spo
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008626 increased circulating interleukin-5 level "increase in the amount in the blood of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Faslpr/Faslpr,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: MRL.Cg-Il27ratm1Mak Faslpr

 MP:0008641 increased circulating interleukin-1 beta level "increased in the amount in the blood of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Il10tm1Cgn/Il10tm1Cgn,Il27ratm1Mak/Il27ratm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il27ratm1Mak/Il27ratm1Mak
Genetic Background: B6.129P2-Il27ratm1Mak

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex / reaction
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex / reaction
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex






 

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