ENSMUSG00000003206


Mus musculus

Features
Gene ID: ENSMUSG00000003206
  
Biological name :Ebi3
  
Synonyms : Ebi3 / Interleukin-27 subunit beta / O35228
  
Possible biological names infered from orthology : Epstein-Barr virus induced 3 / Q14213
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 55952623
Gene end: 55957021
  
Corresponding Affymetrix probe sets: 10445977 (MoGene1.0st)   1449222_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000003274
NCBI entrez gene - 50498     See in Manteia.
MGI - MGI:1354171
RefSeq - XM_006524599
RefSeq - NM_015766
RefSeq Peptide - NP_056581
swissprot - O35228
swissprot - Q3U1K3
Ensembl - ENSMUSG00000003206
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ebi3ENSDARG00000053620Danio rerio
 EBI3ENSG00000105246Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P70225 / Il11ra2 / Interleukin-11 receptor subunit alpha-2 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007873529
Q64385 / Il11ra1 / Interleukin-11 receptor subunit alpha-1 / IL11RA* / Q14626* / interleukin 11 receptor subunit alpha*ENSMUSG0000007388929
P70225 / Gm13305 / predicted gene 13305 / Q14626* / IL11RA* / interleukin 11 receptor subunit alpha*ENSMUSG0000007387629
Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*ENSMUSG0000002844428
Il6ra / P22272 / Interleukin-6 receptor subunit alpha / IL6R* / P08887* / interleukin 6 receptor*ENSMUSG0000002794721


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015373  Interferon/interleukin receptor domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0042098 T cell proliferation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity ISO
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045523 interleukin-27 receptor binding IDA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mfrprd6/Mfrprd6
Genetic Background: involves: C3HfB6/Anl

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrp1b-cH/Tyrp1b
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrp1b-cH/Tyrp1b
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0002433 abnormal T helper 1 morphology/development "anomalous structure, formation, or numbers of the subset of helper T cells that enhance cell-mediated immune responses. These cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0002434 abnormal T helper 2 morphology/development "anomalous structure, formation, or numbers of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses. These cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0002962 increased protein excretion "greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0008091 decreased T-helper 2 cell number "reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008588 abnormal circulating interleukin level "anomaly in the amount in the blood of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Tyrp1b-cH/Tyrp1b
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0008602 increased circulating interleukin-4 level "increase in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0008614 increased circulating interleukin-17 level "increase in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Tyrp1b-cH/Tyrp1b
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Tyrp1b-cH/Tyrp1b
Genetic Background: involves: 101/H * C3H/HeH * T Stock

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Mc1rtaw/Mc1re
Genetic Background: involves: M. m. molossinus * C57BL/6J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0010065 decreased circulating creatine level "reduction in the amount per unit of blood of an amino acid that is found in muscle tissue of vertebrates as phosphocreatine and supplies energy for muscle contraction when metabolized" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0011320 abnormal glomerular capillary morphology "any structural anomaly of the small branching blood vessels in the kidney glomerulus that receives blood from the kidney afferent arterioles; these capillaries are under high pressure for filtering within the glomerulus" [MGI:csmith]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

 MP:0011445 abnormal renal protein reabsorption "any anomaly in the process in which proteins are taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0097017]
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Allelic Composition: Ebi3tm1Nkma/Ebi3tm1Nkma,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ebi3tm1Nkma Faslpr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020368 Canx / P35564 / Calnexin / P27824*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex / reaction
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex / reaction
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex
 ENSMUSG00000004040 Stat3 / P42227 / Signal transducer and activator of transcription 3 / P40763*  / complex






 

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