ENSMUSG00000020368


Mus musculus

Features
Gene ID: ENSMUSG00000020368
  
Biological name :Canx
  
Synonyms : Calnexin / Canx / P35564
  
Possible biological names infered from orthology : P27824
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B1.3
Gene start: 50293961
Gene end: 50325673
  
Corresponding Affymetrix probe sets: 10385599 (MoGene1.0st)   10338471 (MoGene1.0st)   10338920 (MoGene1.0st)   10339065 (MoGene1.0st)   10339375 (MoGene1.0st)   10339545 (MoGene1.0st)   10339578 (MoGene1.0st)   10339737 (MoGene1.0st)   10340370 (MoGene1.0st)   10341299 (MoGene1.0st)   10341596 (MoGene1.0st)   10341699 (MoGene1.0st)   10342067 (MoGene1.0st)   10342210 (MoGene1.0st)   10342490 (MoGene1.0st)   10342763 (MoGene1.0st)   10342828 (MoGene1.0st)   10343374 (MoGene1.0st)   10343512 (MoGene1.0st)   10343572 (MoGene1.0st)   10344333 (MoGene1.0st)   10344433 (MoGene1.0st)   10344476 (MoGene1.0st)   10338595 (MoGene1.0st)   10339188 (MoGene1.0st)   10339488 (MoGene1.0st)   10340052 (MoGene1.0st)   10340377 (MoGene1.0st)   10340965 (MoGene1.0st)   10341219 (MoGene1.0st)   10341571 (MoGene1.0st)   10341710 (MoGene1.0st)   10342583 (MoGene1.0st)   10342821 (MoGene1.0st)   10343319 (MoGene1.0st)   10343377 (MoGene1.0st)   10343563 (MoGene1.0st)   10343864 (MoGene1.0st)   10343971 (MoGene1.0st)   1415692_s_at (Mouse Genome 430 2.0 Array)   1422845_at (Mouse Genome 430 2.0 Array)   1428935_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020637
Ensembl peptide - ENSMUSP00000137440
NCBI entrez gene - 12330     See in Manteia.
MGI - MGI:88261
RefSeq - NM_007597
RefSeq - NM_001110499
RefSeq - NM_001110500
RefSeq Peptide - NP_001103969
RefSeq Peptide - NP_001103970
RefSeq Peptide - NP_031623
swissprot - P35564
swissprot - Q5SUC3
Ensembl - ENSMUSG00000020368
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 canxENSDARG00000037488Danio rerio
 CANXENSGALG00000032148Gallus gallus
 CANXENSG00000127022Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Clgn / P52194 / Mus musculus calmegin (Clgn), transcript variant 2, mRNA. / O14967* / calmegin*ENSMUSG0000000219057
Calr / P14211 / Calreticulin / P27797*ENSMUSG0000000381429
Calr4 / calreticulin 4ENSMUSG0000002855826
Calr3 / Q9D9Q6 / Calreticulin-3 / Q96L12*ENSMUSG0000001973220


Protein motifs (from Interpro)
Interpro ID Name
 IPR001580  Calreticulin/calnexin
 IPR009033  Calreticulin/calnexin, P domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018124  Calreticulin/calnexin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0048488 synaptic vesicle endocytosis IMP
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0072583 clathrin-dependent endocytosis IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane ISS
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IEA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation
Interleukin-35 Signalling
Calnexin/calreticulin cycle
Interleukin-27 signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005356 positive geotaxis "mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005357 retropulsion "when placed in a new environment, mice will walk backwards and then may walk forwards, whereas wild type mice will immediately walk forward, or freeze momentarily and then walk forward" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:79604]
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

Allelic Composition: Canxtm1.1Den/Canxtm1.1Den
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008128 abnormal brain internal capsule morphology "any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009976 abnormal cerebellar peduncle morphology "any structural anomaly of any of the three large paired bundles of nerve fibers that connect the cerebellum to the brain stem" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CanxGt(KST286)Byg/CanxGt(KST286)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Col2a1Dmm/Col2a1+
Genetic Background: involves: 101 * C3H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003402 O08795 / Prkcsh / protein kinase C substrate 80K-H / P14314*  / reaction
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / reaction / complex
 ENSMUSG00000036594 H2-Aa / P14434 / H-2 class II histocompatibility antigen, A-B alpha chain / P01909* / P01906* / HLA-DQA2* / HLA-DQA1* / major histocompatibility complex, class II, DQ alpha 2* / major hist...  / complex / reaction
 ENSMUSG00000060586 H2-Eb1 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000027248 Pdia3 / P27773 / Protein disulfide-isomerase A3 / P30101* / protein disulfide isomerase family A member 3*  / complex / reaction
 ENSMUSG00000073421 H2-Ab1 / P14483 / histocompatibility 2, class II antigen A, beta 1 / P05538* / HLA-DQB1* / HLA-DQB2* / major histocompatibility complex, class II, DQ beta 1* / major histocompatibility comp...  / reaction / complex
 ENSMUSG00000067341 H2-Eb2 / Q9GIY3* / P01911* / P04229* / Q29974* / Q30154* / HLA-DRB5* / HLA-DRB1* / major histocompatibility complex, class II, DR beta 1* / major histocompatibility complex, class II, DR beta 5*  / reaction / complex
 ENSMUSG00000003814 Calr / P14211 / Calreticulin / P27797*  / complex
 ENSMUSG00000060802 B2m / P01887 / Beta-2-microglobulin / P61769*  / reaction
 ENSMUSG00000024610 Cd74 / P04441 / CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated) / P04233* / CD74 molecule*  / complex / reaction
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex
 ENSMUSG00000044701 Il27 / Q8K3I6 / Interleukin-27 subunit alpha / Q8NEV9* / interleukin 27*  / complex
 ENSMUSG00000071650 Ganab / Q8BHN3 / Neutral alpha-glucosidase AB / Q14697* / glucosidase II alpha subunit*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr