ENSG00000127022


Homo sapiens

Features
Gene ID: ENSG00000127022
  
Biological name :CANX
  
Synonyms : calnexin / CANX / P27824
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q35.3
Gene start: 179678628
Gene end: 179730925
  
Corresponding Affymetrix probe sets: 200068_s_at (Human Genome U133 Plus 2.0 Array)   208852_s_at (Human Genome U133 Plus 2.0 Array)   208853_s_at (Human Genome U133 Plus 2.0 Array)   238034_at (Human Genome U133 Plus 2.0 Array)   238138_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000421434
Ensembl peptide - ENSP00000421813
Ensembl peptide - ENSP00000427115
Ensembl peptide - ENSP00000426555
Ensembl peptide - ENSP00000426425
Ensembl peptide - ENSP00000426052
Ensembl peptide - ENSP00000425246
Ensembl peptide - ENSP00000424745
Ensembl peptide - ENSP00000424740
Ensembl peptide - ENSP00000424341
Ensembl peptide - ENSP00000424140
Ensembl peptide - ENSP00000424063
Ensembl peptide - ENSP00000247461
Ensembl peptide - ENSP00000391646
Ensembl peptide - ENSP00000421107
NCBI entrez gene - 821     See in Manteia.
OMIM - 114217
RefSeq - NM_001746
RefSeq - NM_001024649
RefSeq - XM_011534664
RefSeq - XM_011534665
RefSeq Peptide - NP_001019820
RefSeq Peptide - NP_001737
swissprot - D6RD16
swissprot - D6RB85
swissprot - D6RAU8
swissprot - D6RHJ3
swissprot - H0Y9H1
swissprot - H0Y9Q7
swissprot - P27824
swissprot - D6RAQ8
swissprot - D6RGY2
swissprot - D6RG29
swissprot - D6RFW4
swissprot - D6RFL1
swissprot - D6RDP7
Ensembl - ENSG00000127022
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 canxENSDARG00000037488Danio rerio
 CANXENSGALG00000032148Gallus gallus
 CanxENSMUSG00000020368Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLGN / O14967 / calmeginENSG0000015313259
CALR / P27797 / calreticulinENSG0000017921830
CALR3 / Q96L12 / calreticulin 3ENSG0000026905820


Protein motifs (from Interpro)
Interpro ID Name
 IPR001580  Calreticulin/calnexin
 IPR009033  Calreticulin/calnexin, P domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018124  Calreticulin/calnexin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0009306 protein secretion TAS
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0034975 protein folding in endoplasmic reticulum TAS
 biological_processGO:0048488 synaptic vesicle endocytosis ISS
 biological_processGO:0061077 chaperone-mediated protein folding IEA
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 biological_processGO:0072583 clathrin-dependent endocytosis ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IDA
 cellular_componentGO:0005790 smooth endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane TAS
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0034185 apolipoprotein binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
Assembly of Viral Components at the Budding Site
MHC class II antigen presentation
Interleukin-35 Signalling
Calnexin/calreticulin cycle
Interleukin-27 signaling
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / reaction / complex
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex / reaction
 ENSG00000167004 PDIA3 / P30101 / protein disulfide isomerase family A member 3  / complex / reaction
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex
 ENSG00000179218 CALR / P27797 / calreticulin  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / reaction / complex
 ENSG00000089597 GANAB / Q14697 / glucosidase II alpha subunit  / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / reaction
 ENSG00000197272 IL27 / Q8NEV9 / interleukin 27  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000130175 P14314 / PRKCSH / protein kinase C substrate 80K-H  / reaction






 

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