ENSG00000197272


Homo sapiens

Features
Gene ID: ENSG00000197272
  
Biological name :IL27
  
Synonyms : IL27 / interleukin 27 / Q8NEV9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p11.2
Gene start: 28499362
Gene end: 28512051
  
Corresponding Affymetrix probe sets: 1552995_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349365
Ensembl peptide - ENSP00000455990
NCBI entrez gene - 246778     See in Manteia.
OMIM - 608273
RefSeq - XM_011545780
RefSeq - NM_145659
RefSeq Peptide - NP_663634
swissprot - Q8NEV9
swissprot - H3BQY2
Ensembl - ENSG00000197272
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Il27ENSMUSG00000044701Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026207  Interleukin-27 alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002230 positive regulation of defense response to virus by host IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042129 regulation of T cell proliferation IBA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045625 regulation of T-helper 1 cell differentiation IDA
 biological_processGO:0050688 regulation of defense response to virus IEA
 biological_processGO:0070106 interleukin-27-mediated signaling pathway TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045523 interleukin-27 receptor binding IBA


Pathways (from Reactome)
Pathway description
Interleukin-27 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / reaction / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000168610 STAT3 / P40763 / signal transducer and activator of transcription 3  / complex
 ENSG00000006016 CRLF1 / O75462 / cytokine receptor like factor 1  / complex
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex
 ENSG00000127022 CANX / P27824 / calnexin  / complex
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr