ENSG00000167004


Homo sapiens

Features
Gene ID: ENSG00000167004
  
Biological name :PDIA3
  
Synonyms : P30101 / PDIA3 / protein disulfide isomerase family A member 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.3
Gene start: 43746392
Gene end: 43773279
  
Corresponding Affymetrix probe sets: 208612_at (Human Genome U133 Plus 2.0 Array)   227033_at (Human Genome U133 Plus 2.0 Array)   229453_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000389906
Ensembl peptide - ENSP00000391111
Ensembl peptide - ENSP00000398005
Ensembl peptide - ENSP00000300289
NCBI entrez gene - 2923     See in Manteia.
OMIM - 602046
RefSeq - NM_005313
RefSeq Peptide - NP_005304
swissprot - V9HVY3
swissprot - F8WBS6
swissprot - F8WBW5
swissprot - H7BZJ3
swissprot - P30101
Ensembl - ENSG00000167004
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdia3ENSDARG00000102640Danio rerio
 PDIA3ENSGALG00000008348Gallus gallus
 Pdia3ENSMUSG00000027248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PDIA4 / P13667 / protein disulfide isomerase family A member 4ENSG0000015566040
P4HB / P07237 / prolyl 4-hydroxylase subunit betaENSG0000018562432
PDIA2 / Q13087 / protein disulfide isomerase family A member 2ENSG0000018561528
PDILT / Q8N807 / protein disulfide isomerase like, testis expressedENSG0000016934022
ERP44 / Q9BS26 / endoplasmic reticulum protein 44ENSG0000002331817
TMX3 / Q96JJ7 / thioredoxin related transmembrane protein 3ENSG0000016647916
ERP27 / Q96DN0 / endoplasmic reticulum protein 27ENSG0000013905510


Protein motifs (from Interpro)
Interpro ID Name
 IPR005788  Disulphide isomerase
 IPR005792  Protein disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002474 antigen processing and presentation of peptide antigen via MHC class I TAS
 biological_processGO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006606 protein import into nucleus TAS
 biological_processGO:0006621 protein retention in ER lumen TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0034975 protein folding in endoplasmic reticulum TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress IBA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0043209 myelin sheath IEA
 cellular_componentGO:0045335 phagocytic vesicle TAS
 cellular_componentGO:0055038 recycling endosome membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0003756 protein disulfide isomerase activity IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity TAS
 molecular_functionGO:0004629 phospholipase C activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015036 disulfide oxidoreductase activity TAS
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
ER-Phagosome pathway
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000127022 CANX / P27824 / calnexin  / complex / reaction
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000179218 CALR / P27797 / calreticulin  / reaction / complex
 ENSG00000089597 GANAB / Q14697 / glucosidase II alpha subunit  / reaction
 ENSG00000130175 P14314 / PRKCSH / protein kinase C substrate 80K-H  / reaction






 

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