ENSG00000185615


Homo sapiens

Features
Gene ID: ENSG00000185615
  
Biological name :PDIA2
  
Synonyms : PDIA2 / protein disulfide isomerase family A member 2 / Q13087
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.3
Gene start: 283152
Gene end: 287215
  
Corresponding Affymetrix probe sets: 206691_s_at (Human Genome U133 Plus 2.0 Array)   216127_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405081
Ensembl peptide - ENSP00000219406
Ensembl peptide - ENSP00000384410
Ensembl peptide - ENSP00000392277
NCBI entrez gene - 64714     See in Manteia.
OMIM - 608012
RefSeq - NM_006849
RefSeq Peptide - NP_006840
swissprot - H0Y4J5
swissprot - Q13087
swissprot - Q4TT65
Ensembl - ENSG00000185615
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pdia2ENSDARG00000018263Danio rerio
 PDIA2ENSGALG00000040070Gallus gallus
 Pdia2ENSMUSG00000024184Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
P4HB / P07237 / prolyl 4-hydroxylase subunit betaENSG0000018562446
PDILT / Q8N807 / protein disulfide isomerase like, testis expressedENSG0000016934032
PDIA4 / P13667 / protein disulfide isomerase family A member 4ENSG0000015566029
PDIA3 / P30101 / protein disulfide isomerase family A member 3ENSG0000016700427
ERP44 / Q9BS26 / endoplasmic reticulum protein 44ENSG0000002331816
TMX3 / Q96JJ7 / thioredoxin related transmembrane protein 3ENSG0000016647915
ERP27 / Q96DN0 / endoplasmic reticulum protein 27ENSG0000013905514


Protein motifs (from Interpro)
Interpro ID Name
 IPR005792  Protein disulphide isomerase
 IPR013766  Thioredoxin domain
 IPR017937  Thioredoxin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006621 protein retention in ER lumen TAS
 biological_processGO:0019511 peptidyl-proline hydroxylation IEA
 biological_processGO:0034975 protein folding in endoplasmic reticulum TAS
 biological_processGO:0034976 response to endoplasmic reticulum stress IBA
 biological_processGO:0045454 cell redox homeostasis IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 biological_processGO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IBA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 molecular_functionGO:0003756 protein disulfide isomerase activity IBA
 molecular_functionGO:0005496 steroid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0015036 disulfide oxidoreductase activity TAS
 molecular_functionGO:0015037 peptide disulfide oxidoreductase activity IDA
 molecular_functionGO:0016853 isomerase activity IEA
 molecular_functionGO:0031545 peptidyl-proline 4-dioxygenase activity IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr