ENSMUSG00000018341


Mus musculus

Features
Gene ID: ENSMUSG00000018341
  
Biological name :Il12rb2
  
Synonyms : Il12rb2 / Interleukin-12 receptor subunit beta-2 / P97378
  
Possible biological names infered from orthology : Q99665
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C1
Gene start: 67291318
Gene end: 67376188
  
Corresponding Affymetrix probe sets: 10545135 (MoGene1.0st)   1421623_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000010605
Ensembl peptide - ENSMUSP00000113267
NCBI entrez gene - 16162     See in Manteia.
MGI - MGI:1270861
RefSeq - XM_006505617
RefSeq - NM_001311141
RefSeq - NM_008354
RefSeq Peptide - NP_001298070
RefSeq Peptide - NP_032380
swissprot - P97378
swissprot - D3Z6H5
Ensembl - ENSMUSG00000018341
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il12rb2ENSDARG00000052157Danio rerio
 IL12RB2ENSGALG00000011222Gallus gallus
 Q99665ENSG00000081985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*ENSMUSG0000002175620
Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*ENSMUSG0000005426318
Csf3r / P40223 / Granulocyte colony-stimulating factor receptor / Q99062* / colony stimulating factor 3 receptor*ENSMUSG0000002885918
Il31ra / Q8K5B1 / Interleukin-31 receptor subunit alpha / Q8NI17* / interleukin 31 receptor A*ENSMUSG0000005037716
Osmr / oncostatin M receptor / Q99650*ENSMUSG0000002214616


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IGI
 biological_processGO:0032609 interferon-gamma production IGI
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0034097 response to cytokine IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IPI


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0001819 abnormal immune cell physiology "abnormal function of the cells of the immune system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kittm1Bpr/Kittm1Bpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0001870 salivary gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the salivary gland" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kittm1Bpr/Kittm1Bpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kittm1Bpr/Kittm1Bpr
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * C57BL/6)

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ift88tm1.1(KOMP)Vlcg/Ift88tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Ift88tm1.1(KOMP)Vlcg/J

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008217 abnormal B cell activation "any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific" [GO:0002312, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008714 lung carcinoma "a malignant neoplasm of the ling, arising from epithelial cells, usually glandular or squamous" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0008879 submandibular gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0010144 abnormal tumor vascularization "aberrant process of blood vessel formation and the subsequent remodeling process within and/or around tumors" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0010286 increased plasmacytoma incidence "greater than the expected number of neoplastic plasma cells in bone or in one of the extramedullary sites occurring in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Ikbkbtm1Trk/Ikbkbtm1Trk
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Il12rb2Ifnm-d/Il12rb2Ifnm-d,Tlr4lps-del/Tlr4lps-del
Genetic Background: C57BL/10ScCr

 MP:0013367 parotid gland inflammation "local accumulation of fluid, plasma proteins, and leukocytes in either of the largest of the major salivary glands situated below and in front of each ear " [MGI:Anna]
Show

Allelic Composition: Gria2tm1Rod/Gria2+
Genetic Background: B6.129-Gria2tm1Rod/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000000791 Q60837 / Il12rb1 / Interleukin-12 receptor subunit beta-1 / P42701*  / reaction / complex
 ENSMUSG00000032175 Tyk2 / tyrosine kinase 2 / P29597*  / complex / reaction
 ENSMUSG00000003206 Ebi3 / O35228 / Interleukin-27 subunit beta / Q14213* / Epstein-Barr virus induced 3*  / complex
 ENSMUSG00000005465 Il27ra / O70394 / Interleukin-27 receptor subunit alpha / Q6UWB1*  / complex
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / complex
 ENSMUSG00000062939 Stat4 / signal transducer and activator of transcription 4 / Q14765*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / complex
 ENSMUSG00000018341 P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*  / complex
 ENSMUSG00000004296 Il12b / P43432 / Interleukin-12 subunit beta / P29460* / interleukin 12B*  / complex / reaction
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000027776 Il12a / P43431 / interleukin 12a / P29459*  / complex / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr