ENSMUSG00000050377


Mus musculus

Features
Gene ID: ENSMUSG00000050377
  
Biological name :Il31ra
  
Synonyms : Il31ra / Interleukin-31 receptor subunit alpha / Q8K5B1
  
Possible biological names infered from orthology : interleukin 31 receptor A / Q8NI17
  
Species: Mus musculus
  
Chr. number: 13
Strand: -1
Band: D2.2
Gene start: 112519898
Gene end: 112594360
  
Corresponding Affymetrix probe sets: 10412126 (MoGene1.0st)   1451535_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152979
Ensembl peptide - ENSMUSP00000153660
Ensembl peptide - ENSMUSP00000153425
Ensembl peptide - ENSMUSP00000153382
Ensembl peptide - ENSMUSP00000153298
Ensembl peptide - ENSMUSP00000058045
NCBI entrez gene - 218624     See in Manteia.
MGI - MGI:2180511
RefSeq - XM_017315500
RefSeq - XM_017315499
RefSeq - XM_006517620
RefSeq - NM_139299
RefSeq - XM_006517621
RefSeq - XM_006517623
RefSeq Peptide - NP_647460
swissprot - Q8K5B1
swissprot - A0A286YE03
swissprot - A0A286YCG5
swissprot - A0A286YD69
swissprot - A0A286YDE2
Ensembl - ENSMUSG00000050377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL31RAENSGALG00000030800Gallus gallus
 IL31RAENSG00000164509Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*ENSMUSG0000002175624
Csf3r / P40223 / Granulocyte colony-stimulating factor receptor / Q99062* / colony stimulating factor 3 receptor*ENSMUSG0000002885921
P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*ENSMUSG0000001834120
Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*ENSMUSG0000005426316
Osmr / oncostatin M receptor / Q99650*ENSMUSG0000002214616


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002067 glandular epithelial cell differentiation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IMP
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0035745 T-helper 2 cell cytokine production IMP
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0098542 defense response to other organism IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0004896 cytokine receptor activity ISO
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019955 cytokine binding IPI


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0002500 granulomatous inflammation "chronic inflammation resulting from the failure of the acute inflammatory response and persistance of the injurious agent; characterized by a central area of marcophages, often fused into giant cells, and surrounded by T cells " [Pathology:ISBN 0-397-51047-0, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhx3tm1(cre)Slp/Lhx3tm1(cre)Slp
Genetic Background: involves: 129S1/Sv

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Sox17tm1Sjm/Sox17tm1Sjm
Genetic Background: BKa.129-Sox17tm1Sjm

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / complex
 ENSMUSG00000022146 Osmr / oncostatin M receptor / Q99650*  / complex
 ENSMUSG00000029437 Il31 / Q6EAL8 / Interleukin-31 / Q6EBC2*  / complex






 

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