ENSG00000164509


Homo sapiens

Features
Gene ID: ENSG00000164509
  
Biological name :IL31RA
  
Synonyms : IL31RA / interleukin 31 receptor A / Q8NI17
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: 1
Band: q11.2
Gene start: 55851379
Gene end: 55922853
  
Corresponding Affymetrix probe sets: 1553032_at (Human Genome U133 Plus 2.0 Array)   1555431_a_at (Human Genome U133 Plus 2.0 Array)   243541_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427533
Ensembl peptide - ENSP00000415900
Ensembl peptide - ENSP00000479432
Ensembl peptide - ENSP00000297015
Ensembl peptide - ENSP00000347047
Ensembl peptide - ENSP00000351935
Ensembl peptide - ENSP00000380046
Ensembl peptide - ENSP00000380048
NCBI entrez gene - 133396     See in Manteia.
OMIM - 609510
RefSeq - XM_011543145
RefSeq - NM_001242636
RefSeq - NM_001242637
RefSeq - NM_001242638
RefSeq - NM_001242639
RefSeq - NM_001297570
RefSeq - NM_001297572
RefSeq - NM_139017
RefSeq - XM_011543142
RefSeq - XM_011543143
RefSeq - XM_011543144
RefSeq Peptide - NP_001229568
RefSeq Peptide - NP_001284499
RefSeq Peptide - NP_001284501
RefSeq Peptide - NP_620586
RefSeq Peptide - NP_001229566
RefSeq Peptide - NP_001229567
RefSeq Peptide - NP_001229565
swissprot - Q8NI17
swissprot - A0A0C4DGU4
Ensembl - ENSG00000164509
  
Related genetic diseases (OMIM): 613955 - ?Amyloidosis, primary localized cutaneous, 2, 613955
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IL31RAENSGALG00000030800Gallus gallus
 Il31raENSMUSG00000050377Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL6ST / P40189 / interleukin 6 signal transducerENSG0000013435225
CSF3R / Q99062 / colony stimulating factor 3 receptorENSG0000011953521
Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2ENSG0000008198520
LIFR / P42702 / LIF receptor alphaENSG0000011359417
OSMR / Q99650 / oncostatin M receptorENSG0000014562316


Protein motifs (from Interpro)
Interpro ID Name
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR015321  Type I cytokine receptor, cytokine-binding domain
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade NAS
 biological_processGO:0002067 glandular epithelial cell differentiation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0006952 defense response NAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0007259 JAK-STAT cascade IEP
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030224 monocyte differentiation IEP
 biological_processGO:0030225 macrophage differentiation NAS
 biological_processGO:0035745 T-helper 2 cell cytokine production IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEP
 biological_processGO:0042592 homeostatic process NAS
 biological_processGO:0043031 negative regulation of macrophage activation NAS
 biological_processGO:0043066 negative regulation of apoptotic process NAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated NAS
 biological_processGO:0098542 defense response to other organism IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0042734 presynaptic membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0003713 transcription coactivator activity NAS
 molecular_functionGO:0004896 cytokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding NAS
 molecular_functionGO:0019955 cytokine binding NAS


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000989 Pruritus "Pruritus is an itch or a sensation that makes a person want to scratch. This term refers to an abnormally increased disposition to experience pruritus." [HPO:curators]
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 HP:0012309 Cutaneous amyloidosis "The presence of `amyloid deposition` (MPATH:34) in the superficial dermis." [HPO:probinson, pmid:19690585]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000145623 OSMR / Q99650 / oncostatin M receptor  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000204671 IL31 / Q6EBC2 / interleukin 31  / complex






 

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