ENSG00000081985


Homo sapiens

Features
Gene ID: ENSG00000081985
  
Biological name :IL12RB2
  
Synonyms : IL12RB2 / interleukin 12 receptor subunit beta 2 / Q99665
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p31.3
Gene start: 67307364
Gene end: 67396900
  
Corresponding Affymetrix probe sets: 206999_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000262345
Ensembl peptide - ENSP00000400959
Ensembl peptide - ENSP00000442443
Ensembl peptide - ENSP00000445276
Ensembl peptide - ENSP00000360039
NCBI entrez gene - 3595     See in Manteia.
OMIM - 601642
RefSeq - XM_017001204
RefSeq - XM_005270825
RefSeq - XM_005270827
RefSeq - XM_005270828
RefSeq - XM_006710617
RefSeq - XM_011541383
RefSeq - XM_011541384
RefSeq - XM_017001202
RefSeq - XM_017001203
RefSeq - NM_001258214
RefSeq - NM_001258215
RefSeq - NM_001258216
RefSeq - NM_001319233
RefSeq - NM_001559
RefSeq Peptide - NP_001306162
RefSeq Peptide - NP_001245143
RefSeq Peptide - NP_001245144
RefSeq Peptide - NP_001550
RefSeq Peptide - NP_001245145
swissprot - Q99665
swissprot - H0Y5V0
swissprot - A0A0A0MTN7
Ensembl - ENSG00000081985
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il12rb2ENSDARG00000052157Danio rerio
 IL12RB2ENSGALG00000011222Gallus gallus
 P97378ENSMUSG00000018341Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CSF3R / Q99062 / colony stimulating factor 3 receptorENSG0000011953521
IL6ST / P40189 / interleukin 6 signal transducerENSG0000013435220
LIFR / P42702 / LIF receptor alphaENSG0000011359420
OSMR / Q99650 / oncostatin M receptorENSG0000014562318
IL31RA / Q8NI17 / interleukin 31 receptor AENSG0000016450917


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IDA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0035722 interleukin-12-mediated signaling pathway TAS
 biological_processGO:0070757 interleukin-35-mediated signaling pathway TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-35 Signalling
Interleukin-12 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000105246 EBI3 / Q14213 / Epstein-Barr virus induced 3  / complex
 ENSG00000113302 IL12B / P29460 / interleukin 12B  / complex / reaction
 ENSG00000105397 TYK2 / P29597 / tyrosine kinase 2  / complex / reaction
 ENSG00000168811 IL12A / P29459 / interleukin 12A  / complex / reaction
 ENSG00000115415 STAT1 / P42224 / signal transducer and activator of transcription 1  / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex
 ENSG00000096996 P42701 / IL12RB1 / interleukin 12 receptor subunit beta 1  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000104998 IL27RA / Q6UWB1 / interleukin 27 receptor subunit alpha  / complex
 ENSG00000081985 Q99665 / IL12RB2 / interleukin 12 receptor subunit beta 2  / complex
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex
 ENSG00000138378 STAT4 / Q14765 / signal transducer and activator of transcription 4  / reaction / complex






 

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