| MP:0000208 | decreased hematocrit | "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001554 | increased circulating free fatty acid level | "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001577 | anemia | "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002079 | increased circulating insulin level | "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002123 | abnormal hematopoiesis | "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002413 | abnormal megakaryoblast morphology/development | "anomalous structure or development of the progenitor cells of the thrombocytic (platelet) line of cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002875 | decreased erythrocyte count | "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0002981 | increased liver weight | "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0003179 | decreased platelet count | "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0003645 | increased number of pancreatic beta cells | "greater than normal number of the cells of the pancreas that secrete insulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005293 | impaired glucose tolerance | "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005331 | insulin resistance | "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005559 | increased circulating glucose level | "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005658 | susceptibility to diet-induced obesity | "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0005669 | increased circulating leptin level | "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0006410 | abnormal common myeloid progenitor cell morphology | "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0008255 | decreased megakaryocyte cell number | "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0008553 | increased circulating tumor necrosis factor level | "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0008593 | increased circulating interleukin-10 level | "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0008801 | abnormal erythroid progenitor cell morphology | "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0009288 | increased epididymal fat pad weight | |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0009355 | increased liver triglyceride level | "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
Show
Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0010027 | increased liver cholesterol level | "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0010398 | decreased liver glycogen level | "less than the normal concentration of a readily converted carbohydrate reserve in liver" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0010934 | increased subcutaneous adipose tissue amount | "increase in amount of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0011939 | increased food intake | "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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| MP:0020386 | adipose tissue inflammation | "local accumulation of fluid, plasma proteins, and leukocytes in adipose tissue" [MGI:anna, PMID:24662293, PMID:24695736, PMID:26629401] |
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Allelic Composition: Foxn1tm1Nrm/Foxn1tm1Nrm
Genetic Background: involves: 129X1/SvJ * C57BL/6J
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