ENSMUSG00000028859


Mus musculus

Features
Gene ID: ENSMUSG00000028859
  
Biological name :Csf3r
  
Synonyms : Csf3r / Granulocyte colony-stimulating factor receptor / P40223
  
Possible biological names infered from orthology : colony stimulating factor 3 receptor / Q99062
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.2
Gene start: 126024550
Gene end: 126044440
  
Corresponding Affymetrix probe sets: 10508074 (MoGene1.0st)   1418806_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030673
Ensembl peptide - ENSMUSP00000101768
NCBI entrez gene - 12986     See in Manteia.
MGI - MGI:1339755
RefSeq - XM_017319945
RefSeq - NM_001252651
RefSeq - NM_007782
RefSeq - XM_011240422
RefSeq - XM_011240423
RefSeq - XM_017319944
RefSeq - XM_006502708
RefSeq - XM_006502709
RefSeq - XM_006502710
RefSeq - XM_006502711
RefSeq - XM_006502712
RefSeq - XM_006502713
RefSeq - XM_006502714
RefSeq - XM_006502716
RefSeq - XM_006502717
RefSeq - XM_006502718
RefSeq - XM_011240421
RefSeq Peptide - NP_031808
RefSeq Peptide - NP_001239580
swissprot - P40223
Ensembl - ENSMUSG00000028859
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 csf3rENSDARG00000045959Danio rerio
 CSF3RENSGALG00000002112Gallus gallus
 CSF3RENSG00000119535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*ENSMUSG0000002175624
P97378 / Il12rb2 / Interleukin-12 receptor subunit beta-2 / Q99665*ENSMUSG0000001834119
Il31ra / Q8K5B1 / Interleukin-31 receptor subunit alpha / Q8NI17* / interleukin 31 receptor A*ENSMUSG0000005037718
Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*ENSMUSG0000005426316
Osmr / oncostatin M receptor / Q99650*ENSMUSG0000002214615


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0045637 regulation of myeloid cell differentiation IGI
 biological_processGO:0097186 amelogenesis IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0051916 granulocyte colony-stimulating factor binding IPI


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

Allelic Composition: Csf3rtm2Eur/Csf3rtm2Eur
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: B6.129X1-Csf3rtm4(Epor)Link

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0000321 increased bone marrow cell number "increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: B6.129X1-Csf3rtm4(Epor)Link

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Egr2tm2Jmi/Egr2+
Genetic Background: B6.Cg-Egr2tm2Jmi

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000693 spleen hyperplasia "increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0001102 small superior vagus ganglion "reduced size of the upper ganglion of the vagus nerve located at the jugular foramen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0002396 abnormal hematopoietic system morphology/development "any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0002414 abnormal myeloblast morphology/development "anomalous structure, formation, or numbers of the cells found in the bone marrow that give rise to the granulocyte line of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0002415 abnormal neutrophil morphology/development "anomalous structure, differentiation, or number of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Crybb2Phil/Crybb2Phil
Genetic Background: Swiss Webster

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: B6.129X1-Csf3rtm1Link

 MP:0002620 abnormal monocyte morphology "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: involves: 129X1/SvJ * NIH Black Swiss

 MP:0004931 enlarged epididymis "increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0006410 abnormal common myeloid progenitor cell morphology "anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008111 abnormal granulocyte differentiaton "atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Csf3rtm4(Epor)Link/Csf3rtm4(Epor)Link
Genetic Background: B6.129X1-Csf3rtm4(Epor)Link

Allelic Composition: Csf3rtm1Link/Csf3rtm1Link
Genetic Background: B6.129X1-Csf3rtm1Link

 MP:0009709 hydrometra "an accumulation in the uterine lumen of normal secretions that ordinarily drain from the body but are retained when the cervix or vagina is significantly or completely closed" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Crb2tm1a(KOMP)Wtsi/Crb2+
Genetic Background: C57BL/6N-Crb2tm1a(KOMP)Wtsi/Wtsi

 MP:0010373 myeloid hyperplasia "greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdh2tm1Glr/Cdh2tm1Glr,Olig2tm1(cre)Tmj/Olig2+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Clrn1tm1.1(KOMP)Vlcg/Clrn1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Clrn1tm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000038067 Csf3 / P09920 / Granulocyte colony-stimulating factor / P09919* / colony stimulating factor 3*  / complex / reaction
 ENSMUSG00000028859 Csf3r / P40223 / Granulocyte colony-stimulating factor receptor / Q99062* / colony stimulating factor 3 receptor*  / complex / reaction






 

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