ENSMUSG00000038067


Mus musculus

Features
Gene ID: ENSMUSG00000038067
  
Biological name :Csf3
  
Synonyms : Csf3 / Granulocyte colony-stimulating factor / P09920
  
Possible biological names infered from orthology : colony stimulating factor 3 / P09919
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: D
Gene start: 98701263
Gene end: 98703629
  
Corresponding Affymetrix probe sets: 10380999 (MoGene1.0st)   1419427_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037762
NCBI entrez gene - 12985     See in Manteia.
MGI - MGI:1339751
RefSeq - XM_006532128
RefSeq - NM_009971
RefSeq Peptide - NP_034101
swissprot - P09920
swissprot - Q0VB73
Ensembl - ENSMUSG00000038067
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CSF3ENSGALG00000030907Gallus gallus
 CSF3ENSG00000108342Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009079  Four-helical cytokine-like, core
 IPR030473  Interleukin-6/GCSF/MGF, conserved site
 IPR030474  Interleukin-6/GCSF/MGF


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0030223 neutrophil differentiation IBA
 biological_processGO:0030225 macrophage differentiation IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0030851 granulocyte differentiation NAS
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus IEA
 biological_processGO:0045639 positive regulation of myeloid cell differentiation IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0051897 positive regulation of protein kinase B signaling IEA
 biological_processGO:0061515 myeloid cell development IBA
 biological_processGO:0071345 cellular response to cytokine stimulus IEA
 biological_processGO:2000251 positive regulation of actin cytoskeleton reorganization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity ISO
 molecular_functionGO:0005130 granulocyte colony-stimulating factor receptor binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0019899 enzyme binding IEA


Pathways (from Reactome)
Pathway description
Other interleukin signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Csf1op/Csf1op,Csf2tm1Ard/Csf2tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Csf3tm1Ard/Csf3tm1Ard
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Il6tm1Kopf/Il6tm1Kopf,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C3H * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx1tm1Ysh/Gpx1+,Gpx2tm2Coh/Gpx2tm2Coh
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0004801 increased susceptibility to systemic lupus erythematosus "greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Csf3tm1Ard/Csf3tm1Ard,Junbtm3Wag/Junbtm3Wag,Tg(KRT5-cre)1Tak/0
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C3H * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028859 Csf3r / P40223 / Granulocyte colony-stimulating factor receptor / Q99062* / colony stimulating factor 3 receptor*  / reaction / complex
 ENSMUSG00000038067 Csf3 / P09920 / Granulocyte colony-stimulating factor / P09919* / colony stimulating factor 3*  / complex






 

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