ENSG00000122756


Homo sapiens

Features
Gene ID: ENSG00000122756
  
Biological name :CNTFR
  
Synonyms : ciliary neurotrophic factor receptor / CNTFR / P26992
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: -1
Band: p13.3
Gene start: 34551432
Gene end: 34590140
  
Corresponding Affymetrix probe sets: 205723_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000242338
Ensembl peptide - ENSP00000368265
Ensembl peptide - ENSP00000388082
Ensembl peptide - ENSP00000480451
NCBI entrez gene - 1271     See in Manteia.
OMIM - 118946
RefSeq - XM_017014265
RefSeq - NM_001207011
RefSeq - NM_001842
RefSeq - NM_147164
RefSeq - XM_017014260
RefSeq - XM_017014261
RefSeq - XM_017014262
RefSeq - XM_017014263
RefSeq - XM_017014264
RefSeq Peptide - NP_001833
RefSeq Peptide - NP_671693
RefSeq Peptide - NP_001193940
swissprot - P26992
swissprot - Q5T8H6
Ensembl - ENSG00000122756
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cntfrENSDARG00000028661Danio rerio
 CNTFRENSGALG00000028140Gallus gallus
 CntfrENSMUSG00000028444Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL11RA / Q14626 / interleukin 11 receptor subunit alphaENSG0000013707028
IL6R / P08887 / interleukin 6 receptorENSG0000016071227
EBI3 / Q14213 / Epstein-Barr virus induced 3ENSG0000010524619
AL162231.3ENSG000002587289


Protein motifs (from Interpro)
Interpro ID Name
 IPR003530  Long hematopoietin receptor, soluble alpha chain, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0003360 brainstem development IEA
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007399 nervous system development TAS
 biological_processGO:0007548 sex differentiation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0060538 skeletal muscle organ development IEA
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0019898 extrinsic component of membrane TAS
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex IDA
 cellular_componentGO:0097059 CNTFR-CLCF1 complex IDA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity TAS
 molecular_functionGO:0005102 signaling receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019955 cytokine binding IPI


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / reaction / complex
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / reaction / complex
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / reaction / complex
 ENSG00000242689 CNTF / P26441 / ciliary neurotrophic factor  / complex / reaction
 ENSG00000175505 CLCF1 / Q9UBD9 / cardiotrophin like cytokine factor 1  / complex / reaction
 ENSG00000006016 CRLF1 / O75462 / cytokine receptor like factor 1  / reaction / complex
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / reaction / complex






 

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