ENSG00000242689


Homo sapiens

Features
Gene ID: ENSG00000242689
  
Biological name :CNTF
  
Synonyms : ciliary neurotrophic factor / CNTF / P26441
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q12.1
Gene start: 58622673
Gene end: 58625733
  
Corresponding Affymetrix probe sets: 208597_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355370
NCBI entrez gene - 1270     See in Manteia.
OMIM - 118945
RefSeq - NM_000614
RefSeq Peptide - NP_000605
swissprot - P26441
Ensembl - ENSG00000242689
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CNTFENSGALG00000026207Gallus gallus
 CntfENSMUSG00000079415Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000151  Ciliary neurotrophic factor, CNTF
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040007 growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IEA
 biological_processGO:0046668 regulation of retinal cell programmed cell death IEA
 biological_processGO:0048143 astrocyte activation IBA
 biological_processGO:0048644 muscle organ morphogenesis IEA
 biological_processGO:0048666 neuron development IEA
 biological_processGO:0048680 positive regulation of axon regeneration IBA
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IBA
 cellular_componentGO:0097058 CRLF-CLCF1 complex IDA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding TAS
 molecular_functionGO:0005138 interleukin-6 receptor binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IDA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162434 JAK1 / P23458 / Janus kinase 1  / complex / reaction
 ENSG00000134352 IL6ST / P40189 / interleukin 6 signal transducer  / complex / reaction
 ENSG00000096968 JAK2 / O60674 / Janus kinase 2  / complex / reaction
 ENSG00000113594 LIFR / P42702 / LIF receptor alpha  / reaction / complex
 ENSG00000122756 CNTFR / P26992 / ciliary neurotrophic factor receptor  / reaction / complex






 

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