ENSMUSG00000079415


Mus musculus

Features
Gene ID: ENSMUSG00000079415
  
Biological name :Cntf
  
Synonyms : Ciliary neurotrophic factor / Cntf / P51642
  
Possible biological names infered from orthology : P26441
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 12763660
Gene end: 12765632
  
Corresponding Affymetrix probe sets: 1422033_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108555
NCBI entrez gene - 12803     See in Manteia.
MGI - MGI:88439
RefSeq - NM_170786
RefSeq Peptide - NP_740756
swissprot - P51642
swissprot - Q544D1
Ensembl - ENSMUSG00000079415
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CNTFENSGALG00000026207Gallus gallus
 CNTFENSG00000242689Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000151  Ciliary neurotrophic factor, CNTF
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0040007 growth IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0046533 negative regulation of photoreceptor cell differentiation IDA
 biological_processGO:0046668 regulation of retinal cell programmed cell death IDA
 biological_processGO:0048143 astrocyte activation IBA
 biological_processGO:0048644 muscle organ morphogenesis IGI
 biological_processGO:0048666 neuron development IGI
 biological_processGO:0048680 positive regulation of axon regeneration IBA
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030424 axon IBA
 cellular_componentGO:0097058 CRLF-CLCF1 complex IEA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding IBA
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
IL-6-type cytokine receptor ligand interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

Allelic Composition: Cntftm1Gdy/Cntftm1Gdy
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0000954 reduced oligodendrocyte progenitor number "fewer cells that differentiate into a type of glial cell in the central nervous system" [J:15108]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

 MP:0003354 astrocytosis "a proliferation or spread of astrocytes in the area of a degenerative lesion or damaged tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(Ly6e-MALT1)#Isg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cntftm1Mpin/Cntftm1Mpin,Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003871 abnormal myelin sheath morphology "malformation of the insulating envelope that surrounds nerve fibers or axons" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

 MP:0004981 decreased neuronal precursor cell number "reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Cntftm1Mpin/Cntftm1Mpin,Liftm1Phb/Liftm1Phb
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005405 axon degeneration "retrogressive pathologic change in the single process of a nerve cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

 MP:0006060 increased cerebral infarction size "increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tg(Ly6e-MALT1)#Isg/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

 MP:0009967 abnormal neuron proliferation "any anomaly in the ability of a neuron to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj/Gt(ROSA)26Sortm3(CAG-flpo/ERT2)Alj
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Dclk1tm1.1Jgg/Dclk1+,Dcxtm1Caw/Dcxtm1Caw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * C57BL/6

 MP:0010205 abnormal oligodendrocyte apoptosis "change in the timing or the number of oligodendrocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,C6Q0/C6Q0
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028444 Cntfr / O88507 / Ciliary neurotrophic factor receptor subunit alpha / P26992* / ciliary neurotrophic factor receptor*  / complex / reaction
 ENSMUSG00000024789 Jak2 / Janus kinase 2 / O60674*  / reaction / complex
 ENSMUSG00000028530 Jak1 / Janus kinase 1 / P23458*  / reaction / complex
 ENSMUSG00000021756 Il6st / Q00560 / Interleukin-6 receptor subunit beta / P40189* / interleukin 6 signal transducer*  / reaction / complex
 ENSMUSG00000054263 Lifr / P42703 / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA. / P42702* / LIF receptor alpha*  / reaction / complex






 

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