ENSGALG00000014716


Gallus gallus

Features
Gene ID: ENSGALG00000014716
  
Biological name :IL6ST
  
Synonyms : IL6ST / interleukin 6 signal transducer
  
Possible biological names infered from orthology : Interleukin-6 receptor subunit beta / P40189 / Q00560
  
Species: Gallus gallus
  
Chr. number: Z
Strand: -1
Band:
Gene start: 17028163
Gene end: 17060894
  
Corresponding Affymetrix probe sets: Gga.2225.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000054226
Ensembl peptide - ENSGALP00000023682
NCBI entrez gene - 395684     See in Manteia.
RefSeq - XM_015277242
RefSeq - NM_204871
RefSeq Peptide - NP_990202
swissprot - Q9W6U9
swissprot - A0A1D5PMY8
Ensembl - ENSGALG00000014716
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il6stENSDARG00000104693Danio rerio
 IL6STENSG00000134352Homo sapiens
 Il6stENSMUSG00000021756Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
IL31RA / interleukin 31 receptor A / Q8K5B1* / Q8NI17* / Interleukin-31 receptor subunit alpha *ENSGALG0000003080023
CSF3R / granulocyte colony-stimulating factor receptor / P40223* / Q99062* / colony stimulating factor 3 receptor*ENSGALG0000000211223
IL12RB2 / interleukin-12 receptor subunit beta-2 precursor / P97378* / Q99665* / interleukin 12 receptor subunit beta 2*ENSGALG0000001122219
LIFR / leukemia inhibitory factor receptor precursor / P42702* / P42703* / LIF receptor alpha* / Mus musculus leukemia inhibitory factor receptor (Lifr), transcript variant 3, mRNA.*ENSGALG0000000373318
OSMR / oncostatin M receptor / Q99650*ENSGALG0000000374716


Protein motifs (from Interpro)
Interpro ID Name
 IPR003529  Long hematopoietin receptor, Gp130 family 2, conserved site
 IPR003961  Fibronectin type III
 IPR010457  Immunoglobulin C2-set-like, ligand-binding
 IPR013783  Immunoglobulin-like fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005977 glycogen metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008593 regulation of Notch signaling pathway IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0034097 response to cytokine IEA
 biological_processGO:0038154 interleukin-11-mediated signaling pathway IEA
 biological_processGO:0038165 oncostatin-M-mediated signaling pathway IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0048711 positive regulation of astrocyte differentiation IEA
 biological_processGO:0048861 leukemia inhibitory factor signaling pathway IEA
 biological_processGO:0070102 interleukin-6-mediated signaling pathway IEA
 biological_processGO:0070106 interleukin-27-mediated signaling pathway IEA
 biological_processGO:0070120 ciliary neurotrophic factor-mediated signaling pathway IEA
 cellular_componentGO:0005896 interleukin-6 receptor complex IEA
 cellular_componentGO:0005900 oncostatin-M receptor complex IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044297 cell body IEA
 cellular_componentGO:0070110 ciliary neurotrophic factor receptor complex IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004897 ciliary neurotrophic factor receptor activity IEA
 molecular_functionGO:0004915 interleukin-6 receptor activity IEA
 molecular_functionGO:0004921 interleukin-11 receptor activity IEA
 molecular_functionGO:0004923 leukemia inhibitory factor receptor activity IEA
 molecular_functionGO:0004924 oncostatin-M receptor activity IEA
 molecular_functionGO:0005127 ciliary neurotrophic factor receptor binding IEA
 molecular_functionGO:0005138 interleukin-6 receptor binding IEA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019970 interleukin-11 binding IEA
 molecular_functionGO:0019981 interleukin-6 binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-6 signaling
MAPK1 (ERK2) activation
IL-6-type cytokine receptor ligand interactions
Interleukin-35 Signalling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000004821 PTPN11 / Q90687 / Tyrosine-protein phosphatase non-receptor type 11 / P35235* / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / complex / reaction
 ENSGALG00000007651 STAT1 / signal transducer and activator of transcription 1 / P42224*  / complex / reaction
 ENSGALG00000011031 JAK1 / tyrosine-protein kinase JAK1 / P23458* / Janus kinase 1*  / complex / reaction
 ENSGALG00000026207 CNTF / Q02011 / Ciliary neurotrophic factor / P26441* / P51642*  / reaction / complex
 ENSGALG00000015027 JAK2 / Janus kinase 2 / O60674*  / complex / reaction
 ENSGALG00000014716 IL6ST / interleukin 6 signal transducer / P40189* / Q00560* / Interleukin-6 receptor subunit beta *  / reaction / complex
 ENSGALG00000003267 STAT3 / Q6DV79 / Signal transducer and activator of transcription 3 / P40763* / P42227*  / complex / reaction
 ENSGALG00000033087 STAT4 / signal transducer and activator of transcription 4 / Q14765*  / complex
 ENSGALG00000010915 IL6 / Q90YI0 / Interleukin-6 / P05231* / P08505*  / reaction / complex






 

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