ENSDARG00000045854


Danio rerio

Features
Gene ID: ENSDARG00000045854
  
Biological name :fgf23
  
Synonyms : fgf23 / fibroblast growth factor 23
  
Possible biological names infered from orthology : Q9EPC2 / Q9GZV9
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 5193198
Gene end: 5195027
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000067387
swissprot - Q1L8M3
ZFIN ID - ZDB-GENE-050201-4
Ensembl - ENSDARG00000045854
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FGF23ENSGALG00000027791Gallus gallus
 FGF23ENSG00000118972Homo sapiens
 Fgf23ENSMUSG00000000182Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
fgf19 / fibroblast growth factor 19 / Fgf15* / O95750* / O35622* / Fibroblast growth factor 15 *ENSDARG0000009866320


Protein motifs (from Interpro)
Interpro ID Name
 IPR002209  Fibroblast growth factor family
 IPR008996  Cytokine IL1/FGF
 IPR028304  Fibroblast growth factor 23


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0055074 calcium ion homeostasis IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
PI3K Cascade
PIP3 activates AKT signaling
FGFR4 ligand binding and activation
FGFR3c ligand binding and activation
FGFR1c ligand binding and activation
FGFR1c and Klotho ligand binding and activation
FGFR2c ligand binding and activation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Phospholipase C-mediated cascade: FGFR1
Phospholipase C-mediated cascade; FGFR2
Phospholipase C-mediated cascade; FGFR3
Phospholipase C-mediated cascade; FGFR4
Downstream signaling of activated FGFR1
SHC-mediated cascade:FGFR1
PI-3K cascade:FGFR1
FRS-mediated FGFR1 signaling
PI-3K cascade:FGFR2
SHC-mediated cascade:FGFR2
FRS-mediated FGFR2 signaling
SHC-mediated cascade:FGFR3
FRS-mediated FGFR3 signaling
PI-3K cascade:FGFR3
FRS-mediated FGFR4 signaling
SHC-mediated cascade:FGFR4
PI-3K cascade:FGFR4
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
FGFRL1 modulation of FGFR1 signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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