ENSMUSG00000025020


Mus musculus

Features
Gene ID: ENSMUSG00000025020
  
Biological name :Slit1
  
Synonyms : Q80TR4 / Slit1 / Slit homolog 1 protein
  
Possible biological names infered from orthology : O75093 / slit guidance ligand 1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 41600257
Gene end: 41743665
  
Corresponding Affymetrix probe sets: 10467599 (MoGene1.0st)   1425277_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025993
Ensembl peptide - ENSMUSP00000129034
Ensembl peptide - ENSMUSP00000128381
Ensembl peptide - ENSMUSP00000126139
NCBI entrez gene - 20562     See in Manteia.
MGI - MGI:1315203
RefSeq - XM_011247200
RefSeq - NM_015748
RefSeq Peptide - NP_056563
swissprot - E9Q2P0
swissprot - E9QAW9
swissprot - Q80TR4
swissprot - E9Q117
Ensembl - ENSMUSG00000025020
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit1aENSDARG00000044954Danio rerio
 slit1bENSDARG00000099446Danio rerio
 SLIT1ENSGALG00000042871Gallus gallus
 SLIT1ENSG00000187122Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*ENSMUSG0000003155865
Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*ENSMUSG0000005642760
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*ENSMUSG0000003540315
1 / Crb1 / Q8VHS2 / P82279* / crumbs 1, cell polarity complex component*ENSMUSG0000006368115
Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*ENSMUSG0000003676610
Dll3 / O88516 / Delta-like protein 3 / Q9NYJ7* / delta like canonical Notch ligand 3*ENSMUSG000000034368
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*ENSMUSG000000474287
Dlk1 / delta like non-canonical Notch ligand 1 / P80370*ENSMUSG000000408566


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003645  Follistatin-like, N-terminal
 IPR006207  Cystine knot, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007097 nuclear migration IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008045 motor neuron axon guidance IEA
 biological_processGO:0021772 olfactory bulb development IGI
 biological_processGO:0022028 tangential migration from the subventricular zone to the olfactory bulb IMP
 biological_processGO:0022029 telencephalon cell migration IGI
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IMP
 biological_processGO:0033563 dorsal/ventral axon guidance IGI
 biological_processGO:0048812 neuron projection morphogenesis IGI
 biological_processGO:0048846 axon extension involved in axon guidance IEA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051964 negative regulation of synapse assembly ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048495 Roundabout binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gdnftm1Rosl/Gdnf+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl
Genetic Background: involves: 129/Sv * CD-1

Allelic Composition: Robo3tm1Matl/Robo3tm1Matl,Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129/Sv * CD-1

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0005237 abnormal olfactory tract morphology "structural anomaly of the nervelike, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34460]
Show

Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2+
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Slit1tm1.1Matl/Slit1+,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129S2/SvPas

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0009678 abnormal spinal cord lateral column morphology "any structural anomaly of the region of white matter of the spinal cord that is located between the dorsal and ventral spinal roots" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3tm1.1Dor
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Slit1tm1.1Matl/Slit1tm1.1Matl,Slit2tm1Matl/Slit2tm1Matl,Slit3tm1.1Dor/Slit3+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas

 MP:0009944 abnormal olfactory lobe morphology 
Show

Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Xisttm1Jae/Xisttm2.1Jae
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000051379 Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*  / complex / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / reaction / complex






 

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