MP:0000154 | rib fusion | "appearance of one or more ribs as a single structure" [J:62022, J:62023] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0000155 | asymmetric rib attachment | "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0000352 | decreased cell proliferation | "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0000599 | enlarged liver | "larger than average size of the liver" [J:65146] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0000750 | abnormal muscle regeneration | "inability or defects in ability to repair muscle after injuries" [J:42574] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001548 | hyperlipidemia | "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0001715 | placental labyrinth hypoplasia | "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001716 | abnormal placental labyrinth | "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001732 | postnatal growth retardation | "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Dlk1tm1Hsul/Dlk1+ Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0001846 | increased inflammatory response | "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0001935 | reduced litter size | "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0002058 | neonatal lethality | "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0002082 | postnatal lethality | "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0002362 | abnormal spleen marginal zone morphology | "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002458 | abnormal B cell number | "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002461 | increased circulating immunoglobulin concentration | "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002494 | increased IgM | "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0002628 | fatty liver | "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0003122 | maternal imprinting | "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Dlk1tm1Hsul/Dlk1+ Genetic Background: involves: 129 * C57BL/6J
Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0004201 | fetal growth retardation | "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005076 | abnormal cell differentiation | "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0005178 | increased total circulating cholesterol level | "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005287 | narrow eye opening | "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0005334 | abnormal fat pad | "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
Allelic Composition: Dlk1tm1Hsul/Dlk1+ Genetic Background: involves: 129 * C57BL/6J
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MP:0006094 | adipocyte hypertrophy | "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0008181 | increased marginal zone B cell number | "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008189 | increased transitional stage B cell number | "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008211 | decreased mature B cell number | "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008214 | increased immature B cell number | "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008215 | decreased immature B cell number | "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008470 | abnormal spleen B cell follicle morphology | "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008499 | increased IgG1 level | "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008500 | increased IgG2a level | "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008501 | increased IgG2b level | "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008502 | increased IgG3 level | "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0008803 | abnormal placental labyrinth vasculature morphology | "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0008896 | increased IgG2c level | "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1Srba/Dlk1+ Genetic Background: involves: 129X1/SvJ * C57BL/6
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MP:0009269 | decreased fat cell size | "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0009399 | increased skeletal muscle fiber size | "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009401 | increased skeletal muscle fiber diameter | "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009406 | decreased skeletal muscle fiber number | "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0009419 | skeletal muscle fibrosis | "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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MP:0010769 | abnormal survival | "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0011088 | partial neonatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith] |
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Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)
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MP:0012109 | decreased trophoblast glycogen cell number | "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith] |
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N
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MP:0014169 | decreased brown adipose tissue mass | "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith] |
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+ Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N
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