ENSMUSG00000040856


Mus musculus

Features
Gene ID: ENSMUSG00000040856
  
Biological name :Dlk1
  
Synonyms : delta like non-canonical Notch ligand 1 / Dlk1
  
Possible biological names infered from orthology : P80370
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 109452823
Gene end: 109463336
  
Corresponding Affymetrix probe sets: 10398319 (MoGene1.0st)   1442724_at (Mouse Genome 430 2.0 Array)   1449939_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133430
Ensembl peptide - ENSMUSP00000105472
Ensembl peptide - ENSMUSP00000133530
Ensembl peptide - ENSMUSP00000134308
Ensembl peptide - ENSMUSP00000063104
Ensembl peptide - ENSMUSP00000105467
Ensembl peptide - ENSMUSP00000105468
Ensembl peptide - ENSMUSP00000105469
Ensembl peptide - ENSMUSP00000105470
NCBI entrez gene - 13386     See in Manteia.
MGI - MGI:94900
RefSeq - XM_011243992
RefSeq - NM_001190703
RefSeq - NM_001190704
RefSeq - NM_001190705
RefSeq - NM_010052
RefSeq - XM_006515457
RefSeq Peptide - NP_034182
RefSeq Peptide - NP_001177632
RefSeq Peptide - NP_001177633
RefSeq Peptide - NP_001177634
swissprot - G3UX30
swissprot - G3UZ17
swissprot - B4YB48
swissprot - E9PVN3
swissprot - G3UWU8
swissprot - Q925U3
swissprot - Q9DAU5
swissprot - B4YB46
Ensembl - ENSMUSG00000040856
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01102109.1ENSDARG00000114226Danio rerio
 DLK1ENSGALG00000011244Gallus gallus
 DLK1ENSG00000185559Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*ENSMUSG0000004742834
1 / Crb1 / Q8VHS2 / P82279* / crumbs 1, cell polarity complex component*ENSMUSG0000006368129
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*ENSMUSG0000003540329
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*ENSMUSG0000003155823
Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*ENSMUSG0000005642723
Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*ENSMUSG0000002502023
Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*ENSMUSG0000003676622
Dll3 / O88516 / Delta-like protein 3 / Q9NYJ7* / delta like canonical Notch ligand 3*ENSMUSG0000000343617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000155 asymmetric rib attachment "loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum" [J:19212]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0000750 abnormal muscle regeneration "inability or defects in ability to repair muscle after injuries" [J:42574]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001548 hyperlipidemia "abnormally high concentration of lipids in the circulating blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0001715 placental labyrinth hypoplasia "reduction in cell number of the placental labyrinth, the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0002058 neonatal lethality "death of animal within one day after birth" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0003122 maternal imprinting "specific loci are inactivated during oogenesis and are not expressed in offspring" [llw2:Linda Washburn, Mouse Genome Informatics Curator, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005076 abnormal cell differentiation "anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism s life history" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005287 narrow eye opening "less than the normal distance from one eyelid to the other " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:71350]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0008181 increased marginal zone B cell number "greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008189 increased transitional stage B cell number "greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0008896 increased IgG2c level "greater than normal immunoglobulin class G2c level" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1Srba/Dlk1+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0009399 increased skeletal muscle fiber size "increase in the size of the large multinucleated cells that make up the skeletal muscles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009401 increased skeletal muscle fiber diameter "increased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009406 decreased skeletal muscle fiber number "decreased number of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0009419 skeletal muscle fibrosis "formation of fibrous tissue within skeletal muscle as a result of repair or a reactive process" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

 MP:0010769 abnormal survival "deviation from the expected viability or life span of an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dlk1tm1.2Jvs/Dlk1tm1.2Jvs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Atoh7tm1Gla/Atoh7tm1Gla
Genetic Background: either: (involves: 129S1/Sv * 129S1/SvImJ * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

 MP:0012109 decreased trophoblast glycogen cell number "reduced number of the glycogen-accumulating trophoblast cells that arise in the junctional zone of the placenta" [MGI:csmith]
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Allelic Composition: Dlk1tm1.2Jvs/Dlk1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0014169 decreased brown adipose tissue mass "decreased physical bulk or volume of brown adipose tissue" [MGI:csmith]
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Allelic Composition: Dlk1tm1.1Jvs/Dlk1+,Myf5tm3(cre)Sor/Myf5+
Genetic Background: involves: 129P2 * 129S4/SvJaeSor * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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