Manteia - Molecule gene

ENSMUSG00000003436

Mus musculus

Features

Gene ID:	ENSMUSG00000003436

Biological name :	Dll3

Synonyms :	Delta-like protein 3 / Dll3 / O88516

Possible biological names infered from orthology :	delta like canonical Notch ligand 3 / Q9NYJ7

Species:	Mus musculus

Chr. number:	7
Strand:	-1
Band:	A3
Gene start:	28293553
Gene end:	28302238

Corresponding Affymetrix probe sets:	10561376 (MoGene1.0st) 1449236_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000103951 NCBI entrez gene - 13389 See in Manteia. MGI - MGI:1096877 RefSeq - NM_007866 RefSeq Peptide - NP_031892 swissprot - O88516 swissprot - Q3UND5 Ensembl - ENSMUSG00000003436

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CR456624.1	ENSDARG00000079519	Danio rerio
DLL3	ENSG00000090932	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*	ENSMUSG00000035403	26
1 / Crb1 / Q8VHS2 / P82279* / crumbs 1, cell polarity complex component*	ENSMUSG00000063681	25
Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*	ENSMUSG00000056427	21
Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*	ENSMUSG00000025020	20
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*	ENSMUSG00000031558	20
Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*	ENSMUSG00000036766	19
Dlk1 / delta like non-canonical Notch ligand 1 / P80370*	ENSMUSG00000040856	11
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*	ENSMUSG00000047428	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR000742	EGF-like domain
IPR001881	EGF-like calcium-binding domain
IPR009030	Growth factor receptor cysteine-rich domain superfamily
IPR013032	EGF-like, conserved site

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001501	skeletal system development	IEA
biological_process	GO:0001701	in utero embryonic development	NAS
biological_process	GO:0001709	cell fate determination	NAS
biological_process	GO:0001756	somitogenesis	IMP
biological_process	GO:0007219	Notch signaling pathway	NAS
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007386	compartment pattern specification	IMP
biological_process	GO:0007399	nervous system development	NAS
biological_process	GO:0009888	tissue development	IDA
biological_process	GO:0030154	cell differentiation	IEA
biological_process	GO:0048339	paraxial mesoderm development	IMP
biological_process	GO:0050768	negative regulation of neurogenesis	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0005112	Notch binding	NAS
molecular_function	GO:0005509	calcium ion binding	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rabgef1^tm2Glli/Rabgef1^tm2Glli Genetic Background: WBB6F1
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0000137	abnormal vertebrae morphology	"malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2 Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ Allelic Composition: Dll3^pu/Dll3^pu Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
MP:0000150	abnormal rib morphology	"malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0000153	rib bifurcation	"forking or division of ribs, may be a result of partial rib fusions" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000154	rib fusion	"appearance of one or more ribs as a single structure" [J:62022, J:62023]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2 Allelic Composition: Dll3^pu/Dll3^pu Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000438	abnormal skull morphology	"anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Dll3^pu-2J/Dll3^pu-2J Genetic Background: B6;CBA-Dll3^pu-2J/GrsrJ
MP:0000585	kinked tail	"a sharp bend or zig-zag in the tail" [J:61295]	Show Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2 Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ Allelic Composition: Dll3^pu-2J/Dll3^pu-2J Genetic Background: B6;CBA-Dll3^pu-2J/GrsrJ
MP:0000589	thin tail	"a tail with a smaller diameter than the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0000592	short tail	"reduced length of tail compared to control " [J:55583]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2 Allelic Composition: Dll3^pu/Dll3^pu Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
MP:0000755	hindlimb paralysis	"loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0000961	abnormal dorsal root ganglia morphology	"malformed group of nerve cell bodies of each segmental nerve projecting from the spinal cord " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:60159]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0000963	fused dorsal root ganglia	"loss of DRG spacing pattern and the appearance of two or more ganglia as one " [J:62022, J:62023]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0001077	abnormal spinal nerve morphology	"any anomaly, deformity, or malformation of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0001258	decreased body length	"decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2 Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ Allelic Composition: Dll3^pu/Dll3^pu Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6 Allelic Composition: Dll3^pu-2J/Dll3^pu-2J Genetic Background: B6;CBA-Dll3^pu-2J/GrsrJ
MP:0001539	decreased number of caudal vertebrae	"reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0001688	abnormal somite development	"anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0001691	abnormal somite shape	"atypical characteristic surface configuration of a segmental mass along the notochord of the developing embryo" [J:37888]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0001935	reduced litter size	"fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0002111	abnormal tail morphology	"abnormal development of the tail resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nepro^tm1.1Tets/Nepro^tm1.1Tets Genetic Background: B6JJcl.129(Cg)-Nepro^tm1.1Tets
MP:0002114	abnormal axial skeleton morphology	"abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Htr1a^tm1Toth/Htr1a^tm1Toth Genetic Background: involves: 129P2/OlaHsd * Black Swiss
MP:0002566	abnormal sexual interaction	"altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0002759	abnormal caudal vertebrae morphology	"malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0002907	abnormal parturition	"defect in the process of labor and delivery in female animals " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0003047	abnormal thoracic vertebrae morphology	"malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0003048	abnormal cervical vertebrae morphology	"malformation of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0003049	abnormal lumbar vertebrae morphology	"malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0003051	curly tail	"a loop or corkscrew-like curl in the tail" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^pu-2J/Dll3^pu-2J Genetic Background: B6;CBA-Dll3^pu-2J/GrsrJ
MP:0003345	decreased number of ribs	"fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0003400	kinked neural tube	"twists or kinks in the embryonic neural tube" [J:66514, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0003794	delayed somite formation	"late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0004206	abnormal dermomyotome development	"any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue" [J:50279, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0004599	abnormal vertebral arch morphology	"any structural anomaly of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0004609	vertebral fusion	"the union of one or more vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2
MP:0004626	vertebral compression	"appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0004645	decreased vertebrae number	"a reduction from the normal number of the bony segments of the spinal column" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0004673	splayed ribs	"any deviation from the normal curvature of the ribs such that the ribs are turned outward " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dll3^pu-J/Dll3^pu-J Genetic Background: STOCK Tg(Pfkl)224Yg/J-Dll3^pu-J/GrsrJ
MP:0004704	short vertebral column	"decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0005222	abnormal somite size	"atypical size of any of the segmental masses along the notochord of the developing embryo" [J:72325]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0005225	abnormal vertebrae development	"anomalous formation of the vertebrae from the sclerotome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0005508	abnormal skeleton morphology	"malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6 Allelic Composition: Dll3^pu/Dll3^pu Genetic Background: involves: 101/Rl * C3H/He * C3H/Rl * C57BL/6
MP:0006029	abnormal sclerotome	"malformation of the one or more of the masses of mesodermal tissue that is derived from the somites and is adjacent to the notochord that give rise to the ribs and vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0008271	abnormal bone ossification	"any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]	Show Allelic Composition: Dll3^oma/Dll3^oma Genetic Background: involves: BALB/c * C3H * C57BL/6J * DBA/2
MP:0008317	abnormal paravertebral ganglion morphology	"any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0008530	abnormal rostral-caudal patterning of the somites	"anomaly in the developmental pattern of the somites along the axis that runs from the head to the caudal region of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0010082	sternebra fusion	"appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0010152	abnormal brain ependyma morphology	"any structural anomaly of the cellular membrane that lines the brain ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0012182	abnormal presomitic mesoderm morphology	"any structural anomaly of the unsegmented field of paraxial mesoderm present posterior to the most recently formed somite pair, from which somites will form" [MGI:anna]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N
MP:0012669	abnormal somite segmentation clock	"anomaly or loss of the oscillatory mechanism governed by periodic shifts in gene expression and operating in the presomitic mesoderm that drives the regular periodicity with which somites are formed in the course of vertebrate segmentation. The total number of somites formed and the periodicity with which they are produced are species-specific parameters (e.g. humans have 33 somites with a somitogenesis period of approximately 6 hours while mice have 65 somites with a period of approximately 2 hours)" [http://en.wikipedia.org/wiki/Somitogenesis, MGI:anna, PMID:22274695]	Show Allelic Composition: Dll3^tm1Rbe/Dll3^tm1Rbe Genetic Background: involves: 129P2/Ola * C57BL/6
MP:0012728	abnormal somite border morphology	"any structural anomaly of the anatomical surface separating somites; somite formation requires the physical separation of somitic tissue from the initially continuous presomitic mesoderm (PSM), coalescence of cells in the forming somite, and the establishment of a stable border between the somite and the PSM; when a somite forms in the anterior end of the PSM, an intersomitic boundary (also called a fissure, gap, or cleft) emerges, and it is rapidly followed by a mesenchymal-to-epithelial transition of cells that face a forming gap" [MGI:anna]	Show Allelic Composition: Alx3^tm1Hubr/Alx3^tm1Hubr,Alx4^lst-J/Alx4^lst-J Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6J * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

1 s.

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