ENSMUSG00000036766


Mus musculus

Features
Gene ID: ENSMUSG00000036766
  
Biological name :Dner
  
Synonyms : Delta and Notch-like epidermal growth factor-related receptor / Dner / Q8JZM4
  
Possible biological names infered from orthology : delta/notch like EGF repeat containing / Q8NFT8
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C5
Gene start: 84369839
Gene end: 84696221
  
Corresponding Affymetrix probe sets: 10356177 (MoGene1.0st)   1423671_at (Mouse Genome 430 2.0 Array)   1456379_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042927
Ensembl peptide - ENSMUSP00000140986
Ensembl peptide - ENSMUSP00000140662
NCBI entrez gene - 227325     See in Manteia.
MGI - MGI:2152889
RefSeq - NM_152915
RefSeq Peptide - NP_690879
swissprot - A0A087WSC4
swissprot - A0A087WRJ8
swissprot - Q8JZM4
Ensembl - ENSMUSG00000036766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnerENSDARG00000061031Danio rerio
 DNERENSGALG00000002958Gallus gallus
 DNERENSG00000187957Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
1 / Crb1 / Q8VHS2 / P82279* / crumbs 1, cell polarity complex component*ENSMUSG0000006368127
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*ENSMUSG0000003540325
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*ENSMUSG0000003155822
Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*ENSMUSG0000005642722
Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*ENSMUSG0000002502021
Dll3 / O88516 / Delta-like protein 3 / Q9NYJ7* / delta like canonical Notch ligand 3*ENSMUSG0000000343615
Dlk1 / delta like non-canonical Notch ligand 1 / P80370*ENSMUSG0000004085612
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*ENSMUSG0000004742811


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0048741 skeletal muscle fiber development IDA
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IDA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0000952 abnormal CNS glia "anomalous structure, number or composition of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

 MP:0003894 abnormal Purkinje cell innervation "malformation or absence of the supply of nerve fibers that connect to the Purkinje cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Musktm1.1Vwi/Musktm1.1Vwi
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026923 Notch1 / Q01705 / Neurogenic locus notch homolog protein 1 Notch 1 extracellular truncation Notch 1 intracellular domain / P46531*  / complex / reaction
 ENSMUSG00000029603 Dtx1 / Q61010 / E3 ubiquitin-protein ligase DTX1 / Q86Y01* / deltex E3 ubiquitin ligase 1*  / complex / reaction






 

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