ENSG00000187957


Homo sapiens

Features
Gene ID: ENSG00000187957
  
Biological name :DNER
  
Synonyms : delta/notch like EGF repeat containing / DNER / Q8NFT8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.3
Gene start: 229357629
Gene end: 229714558
  
Corresponding Affymetrix probe sets: 226281_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000345229
NCBI entrez gene - 92737     See in Manteia.
OMIM - 607299
RefSeq - NM_139072
RefSeq - XM_005246950
RefSeq Peptide - NP_620711
swissprot - Q8NFT8
Ensembl - ENSG00000187957
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dnerENSDARG00000061031Danio rerio
 DNERENSGALG00000002958Gallus gallus
 DnerENSMUSG00000036766Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CRB1 / P82279 / crumbs 1, cell polarity complex componentENSG0000013437628
CRB2 / Q5IJ48 / crumbs 2, cell polarity complex componentENSG0000014820426
SLIT2 / O94813 / slit guidance ligand 2ENSG0000014514722
SLIT3 / O75094 / slit guidance ligand 3ENSG0000018434722
SLIT1 / O75093 / slit guidance ligand 1ENSG0000018712221
DLL3 / Q9NYJ7 / delta like canonical Notch ligand 3ENSG0000009093217
DLK1 / P80370 / delta like non-canonical Notch ligand 1ENSG0000018555912
DLK2 / Q6UY11 / delta like non-canonical Notch ligand 2ENSG0000017146212


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration NAS
 biological_processGO:0006897 endocytosis NAS
 biological_processGO:0007219 Notch signaling pathway IEA
 biological_processGO:0007220 Notch receptor processing IEA
 biological_processGO:0007416 synapse assembly NAS
 biological_processGO:0007417 central nervous system development IEP
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0048741 skeletal muscle fiber development IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005509 calcium ion binding NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030276 clathrin binding TAS


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148400 NOTCH1 / P46531  / complex / reaction
 ENSG00000135144 DTX1 / Q86Y01 / deltex E3 ubiquitin ligase 1  / complex / reaction






 

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