ENSG00000185559


Homo sapiens

Features
Gene ID: ENSG00000185559
  
Biological name :DLK1
  
Synonyms : delta like non-canonical Notch ligand 1 / DLK1 / P80370
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q32.2
Gene start: 100725705
Gene end: 100738224
  
Corresponding Affymetrix probe sets: 209560_s_at (Human Genome U133 Plus 2.0 Array)   235600_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000331081
Ensembl peptide - ENSP00000340292
Ensembl peptide - ENSP00000376589
Ensembl peptide - ENSP00000450821
NCBI entrez gene - 8788     See in Manteia.
OMIM - 176290
RefSeq - NM_003836
RefSeq - NM_001317172
RefSeq Peptide - NP_001304101
RefSeq Peptide - NP_003827
swissprot - P80370
swissprot - G3V2R7
swissprot - G3XAH5
Ensembl - ENSG00000185559
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01102109.1ENSDARG00000114226Danio rerio
 DLK1ENSGALG00000011244Gallus gallus
 Dlk1ENSMUSG00000040856Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DLK2 / Q6UY11 / delta like non-canonical Notch ligand 2ENSG0000017146232
CRB2 / Q5IJ48 / crumbs 2, cell polarity complex componentENSG0000014820431
CRB1 / P82279 / crumbs 1, cell polarity complex componentENSG0000013437630
SLIT3 / O75094 / slit guidance ligand 3ENSG0000018434723
SLIT2 / O94813 / slit guidance ligand 2ENSG0000014514723
SLIT1 / O75093 / slit guidance ligand 1ENSG0000018712223
DNER / Q8NFT8 / delta/notch like EGF repeat containingENSG0000018795722
DLL3 / Q9NYJ7 / delta like canonical Notch ligand 3ENSG0000009093218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR013032  EGF-like, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Activated NOTCH1 Transmits Signal to the Nucleus


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000148400 NOTCH1 / P46531  / reaction / complex






 

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