ENSG00000184347


Homo sapiens

Features
Gene ID: ENSG00000184347
  
Biological name :SLIT3
  
Synonyms : O75094 / SLIT3 / slit guidance ligand 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 5
Strand: -1
Band: q35.1
Gene start: 168661733
Gene end: 169301129
  
Corresponding Affymetrix probe sets: 203812_at (Human Genome U133 Plus 2.0 Array)   203813_s_at (Human Genome U133 Plus 2.0 Array)   216216_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000430333
Ensembl peptide - ENSP00000332164
Ensembl peptide - ENSP00000384890
NCBI entrez gene - 6586     See in Manteia.
OMIM - 603745
RefSeq - XM_017009779
RefSeq - NM_001271946
RefSeq - NM_003062
RefSeq Peptide - NP_001258875
RefSeq Peptide - NP_003053
swissprot - O75094
swissprot - A0A0A0MSC8
Ensembl - ENSG00000184347
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 slit3ENSDARG00000034268Danio rerio
 SLIT3ENSGALG00000001916Gallus gallus
 Slit3ENSMUSG00000056427Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SLIT2 / O94813 / slit guidance ligand 2ENSG0000014514766
SLIT1 / O75093 / slit guidance ligand 1ENSG0000018712259
CRB2 / Q5IJ48 / crumbs 2, cell polarity complex componentENSG0000014820415
CRB1 / P82279 / crumbs 1, cell polarity complex componentENSG0000013437615
DNER / Q8NFT8 / delta/notch like EGF repeat containingENSG0000018795710
DLL3 / Q9NYJ7 / delta like canonical Notch ligand 3ENSG000000909328
DLK2 / Q6UY11 / delta like non-canonical Notch ligand 2ENSG000001714627
DLK1 / P80370 / delta like non-canonical Notch ligand 1ENSG000001855596


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006207  Cystine knot, C-terminal
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0032870 cellular response to hormone stimulus IEP
 biological_processGO:0035385 Roundabout signaling pathway IMP
 biological_processGO:0048846 axon extension involved in axon guidance IDA
 biological_processGO:0050919 negative chemotaxis IDA
 biological_processGO:0051414 response to cortisol IEP
 biological_processGO:0061364 apoptotic process involved in luteolysis IEP
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005739 mitochondrion NAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0048495 Roundabout binding IPI


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
Signaling by ROBO receptors
Regulation of commissural axon pathfinding by SLIT and ROBO


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex
 ENSG00000169855 ROBO1 / Q9Y6N7 / roundabout guidance receptor 1  / complex / reaction
 ENSG00000184347 SLIT3 / O75094 / slit guidance ligand 3  / reaction
 ENSG00000185008 ROBO2 / Q9HCK4 / roundabout guidance receptor 2  / complex / reaction






 

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