ENSMUSG00000063681


Mus musculus

Features
Gene ID: ENSMUSG00000063681
  
Biological name :Crb1
  
Synonyms : 1 / Crb1 / Q8VHS2
  
Possible biological names infered from orthology : crumbs 1, cell polarity complex component / P82279
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 139197056
Gene end: 139377100
  
Corresponding Affymetrix probe sets: 10358283 (MoGene1.0st)   1421451_at (Mouse Genome 430 2.0 Array)   1441330_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142702
Ensembl peptide - ENSMUSP00000143386
Ensembl peptide - ENSMUSP00000142909
Ensembl peptide - ENSMUSP00000060769
Ensembl peptide - ENSMUSP00000142552
NCBI entrez gene - 170788     See in Manteia.
MGI - MGI:2136343
RefSeq - XM_017319075
RefSeq - XM_017319069
RefSeq - XM_017319071
RefSeq - XM_006529221
RefSeq - XM_006529217
RefSeq - NM_133239
RefSeq Peptide - NP_573502
swissprot - Q8VHS2
swissprot - A0A0G2JEU4
swissprot - A0A0G2JDY0
swissprot - A0A0G2JG15
Ensembl - ENSMUSG00000063681
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 crb1ENSDARG00000100506Danio rerio
 CRB1ENSGALG00000002287Gallus gallus
 CRB1ENSG00000134376Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
2 / Crb2 / Q80YA8 / Q5IJ48* / crumbs 2, cell polarity complex component*ENSMUSG0000003540331
Slit1 / Q80TR4 / Slit homolog 1 protein / O75093* / slit guidance ligand 1*ENSMUSG0000002502017
Slit2 / Q9R1B9 / slit guidance ligand 2 / O94813*ENSMUSG0000003155817
Slit3 / Q9WVB4 / Slit homolog 3 protein / O75094* / slit guidance ligand 3*ENSMUSG0000005642716
Dner / Q8JZM4 / Delta and Notch-like epidermal growth factor-related receptor / Q8NFT8* / delta/notch like EGF repeat containing*ENSMUSG0000003676614
Dll3 / O88516 / Delta-like protein 3 / Q9NYJ7* / delta like canonical Notch ligand 3*ENSMUSG0000000343610
2 / Dlk2 / Q8K1E3 / Q6UY11* / delta like non-canonical Notch ligand 2*ENSMUSG000000474288
Dlk1 / delta like non-canonical Notch ligand 1 / P80370*ENSMUSG000000408568


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007009 plasma membrane organization IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0061024 membrane organization IMP
 cellular_componentGO:0001917 photoreceptor inner segment IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005902 microvillus IDA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdh23v-7J/Cdh23v-7J
Genetic Background: CByJ(Cg)-Cdh23v-7J/GrsrJ

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: involves: C3HfB6/Ga * C57BL/6 * CAST/EiJ

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: involves: C57BL/6N

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0001999 photosensitivity "alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

 MP:0002864 abnormal ocular fundus morphology "malformation of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0003099 retinal detachment "detachment of the retina from the underlying inner wall of the eye, often from tension of the vitreous; may occur with aging or as a result of trauma" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:83544]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003733 abnormal inner nuclear layer morphology "malformation/anomalous structure of the retinal layer which contains the cell bodies of bipolar, horizontal, and amacrine cells" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Crb1rd8/Crb1rd8,Prkcqtm1Litt/Prkcqtm1Litt
Genetic Background: B6.129P2-Prkcqtm1Litt

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: involves: C57BL/6N

 MP:0005241 abnormal retinal ganglion layer morphology "anomalous structure of the innermost nuclear layer of the retina, which projects axons through the optic nerve to the brain " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Shhtm1Ptch/Shhtm1Ptch
Genetic Background: involves: 129P2/OlaHsd * FVB/N * various

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0008105 increased amacrine cell number "increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0008452 increased retinal rod cell number "greater number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane" [MESH:A08.663.650.650.670.650]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

Allelic Composition: Crb1tm1Wij/Crb1tm2Wij
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008582 short photoreceptor inner segment "decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0008587 short photoreceptor outer segment "decreased length of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

 MP:0009772 abnormal retinal development "anomaly in any of the steps during embryogenesis that produce the nerve layer lining in the back of the eye which senses light, and creates impulses that travel through the optic nerve to the brain" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0010236 abnormal retina outer limiting membrane morphology "any structural anomaly of the row of junctional complexes between the plasma membranes of rod segments and the Muller glia cells; this barrier separates the layer of inner and outer segments of the rods and cones from the outer nuclear layer and forms a blood-retina barrier" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: STOCK Crb1rd8/J

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Gata3tm3Gsv/Gata3tm3Gsv,Tg(KRT14-cre)8Brn/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011964 increased total retina thickness "increased width of the retina through the center plane" [MGI:csmith]
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Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
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Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Crb1tm1Wij/Crb1tm1Wij,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

 MP:0030006 decreased retinal apoptosis "decrease in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Crb1tm1Wij/Crb1+,Crb2tm1.1Wij/Crb2tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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