ENSMUSG00000047787


Mus musculus

Features
Gene ID: ENSMUSG00000047787
  
Biological name :Flrt1
  
Synonyms : Flrt1 / Leucine-rich repeat transmembrane protein FLRT1 / Q6RKD8
  
Possible biological names infered from orthology : fibronectin leucine rich transmembrane protein 1 / Q9NZU1
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: A
Gene start: 7092014
Gene end: 7105729
  
Corresponding Affymetrix probe sets: 10465619 (MoGene1.0st)   1443143_at (Mouse Genome 430 2.0 Array)   1460041_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000109010
NCBI entrez gene - 396184     See in Manteia.
MGI - MGI:3026647
RefSeq - XM_006527171
RefSeq - NM_201411
RefSeq - XM_006527169
RefSeq - XM_006527170
RefSeq Peptide - NP_958813
swissprot - Q6RKD8
Ensembl - ENSMUSG00000047787
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt1bENSDARG00000075597Danio rerio
 FLRT1ENSG00000126500Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flrt3 / Q8BGT1 / Leucine-rich repeat transmembrane protein FLRT3 / Q9NZU0* / fibronectin leucine rich transmembrane protein 3*ENSMUSG0000005137956
Flrt2 / Q8BLU0 / Leucine-rich repeat transmembrane protein FLRT2 / O43155* / fibronectin leucine rich transmembrane protein 2*ENSMUSG0000004741441
Gp1ba / O35930 / glycoprotein 1b, alpha polypeptide / P07359* / glycoprotein Ib platelet alpha subunit*ENSMUSG0000005067517
Nepn / Q9CQ76 / Nephrocan ENSMUSG0000003862415
Omg / oligodendrocyte myelin glycoprotein / P23515*ENSMUSG0000004961213
Lrg1 / leucine rich alpha-2-glycoprotein 1 / P02750*ENSMUSG0000003709512


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IMP
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:1990138 neuron projection extension IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032809 neuronal cell body membrane IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044306 neuron projection terminus IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rps6kb1tm1Gtho/Rps6kb1tm1Gtho,Tg(Ins2-Akt1*)3Mbb/0
Genetic Background: B6.Cg-Rps6kb1tm1Gtho Tg(Ins2-Akt1*)3Mbb

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000058488 Kl / O35082 / Klotho Klotho peptide / klotho* / Q9UEF7*  / reaction / complex
 ENSMUSG00000031565 Fgfr1 / P16092 / Fibroblast growth factor receptor 1 / P11362*  / reaction / complex
 ENSMUSG00000000182 Fgf23 / Q9EPC2 / Fibroblast growth factor 23 / Q9GZV9*  / complex / reaction






 

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