ENSG00000126500


Homo sapiens

Features
Gene ID: ENSG00000126500
  
Biological name :FLRT1
  
Synonyms : fibronectin leucine rich transmembrane protein 1 / FLRT1 / Q9NZU1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64103188
Gene end: 64119173
  
Corresponding Affymetrix probe sets: 210414_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246841
NCBI entrez gene - 23769     See in Manteia.
OMIM - 604806
RefSeq - XM_011544883
RefSeq - NM_013280
RefSeq - XM_005273861
RefSeq Peptide - NP_037412
swissprot - Q9NZU1
Ensembl - ENSG00000126500
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt1bENSDARG00000075597Danio rerio
 Flrt1ENSMUSG00000047787Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLRT3 / Q9NZU0 / fibronectin leucine rich transmembrane protein 3ENSG0000012584857
FLRT2 / O43155 / fibronectin leucine rich transmembrane protein 2ENSG0000018507041
GP1BA / P07359 / glycoprotein Ib platelet alpha subunitENSG0000018524518
OMG / P23515 / oligodendrocyte myelin glycoproteinENSG0000012686113
LRG1 / P02750 / leucine rich alpha-2-glycoprotein 1ENSG0000017123612


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IEA
 biological_processGO:0016358 dendrite development IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:1990138 neuron projection extension IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISS
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0044306 neuron projection terminus IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor NAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030674 protein binding, bridging NAS


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000133116 KL / klotho / Q9UEF7  / reaction / complex
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction






 

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