ENSG00000185070


Homo sapiens

Features
Gene ID: ENSG00000185070
  
Biological name :FLRT2
  
Synonyms : fibronectin leucine rich transmembrane protein 2 / FLRT2 / O43155
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q31.3
Gene start: 85530144
Gene end: 85654426
  
Corresponding Affymetrix probe sets: 204358_s_at (Human Genome U133 Plus 2.0 Array)   204359_at (Human Genome U133 Plus 2.0 Array)   240259_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000332879
Ensembl peptide - ENSP00000451050
NCBI entrez gene - 23768     See in Manteia.
OMIM - 604807
RefSeq - XM_017021135
RefSeq - NM_013231
RefSeq - XM_017021129
RefSeq - XM_017021130
RefSeq - XM_017021131
RefSeq - XM_017021132
RefSeq - XM_017021133
RefSeq - XM_017021134
RefSeq - XM_005267490
RefSeq - XM_011536611
RefSeq Peptide - NP_001333073
RefSeq Peptide - NP_001333074
RefSeq Peptide - NP_001333075
RefSeq Peptide - NP_037363
RefSeq Peptide - NP_001333072
swissprot - O43155
Ensembl - ENSG00000185070
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flrt2ENSDARG00000079355Danio rerio
 flrt2ENSDARG00000097299Danio rerio
 FLRT2ENSGALG00000010589Gallus gallus
 Flrt2ENSMUSG00000047414Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLRT3 / Q9NZU0 / fibronectin leucine rich transmembrane protein 3ENSG0000012584846
FLRT1 / Q9NZU1 / fibronectin leucine rich transmembrane protein 1ENSG0000012650042
GP1BA / P07359 / glycoprotein Ib platelet alpha subunitENSG0000018524517
OMG / P23515 / oligodendrocyte myelin glycoproteinENSG0000012686113
LRG1 / P02750 / leucine rich alpha-2-glycoprotein 1ENSG0000017123611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR032675  Leucine-rich repeat domain superfamily
 IPR036116  Fibronectin type III superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003007 heart morphogenesis ISS
 biological_processGO:0006469 negative regulation of protein kinase activity IBA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway IBA
 biological_processGO:0046426 negative regulation of JAK-STAT cascade IBA
 biological_processGO:0050919 negative chemotaxis IEA
 biological_processGO:0051965 positive regulation of synapse assembly IEA
 biological_processGO:0061343 cell adhesion involved in heart morphogenesis ISS
 biological_processGO:0071711 basement membrane organization ISS
 biological_processGO:2001222 regulation of neuron migration IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane NAS
 cellular_componentGO:0005911 cell-cell junction ISS
 cellular_componentGO:0005925 focal adhesion ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IBA
 molecular_functionGO:0005057 obsolete signal transducer activity, downstream of receptor NAS
 molecular_functionGO:0005104 fibroblast growth factor receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030674 protein binding, bridging NAS
 molecular_functionGO:0045499 chemorepellent activity IEA


Pathways (from Reactome)
Pathway description
Downstream signaling of activated FGFR1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000118972 FGF23 / Q9GZV9 / fibroblast growth factor 23  / complex / reaction
 ENSG00000077782 FGFR1 / P11362 / fibroblast growth factor receptor 1  / complex / reaction
 ENSG00000133116 KL / klotho / Q9UEF7  / reaction / complex






 

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