ENSDARG00000105215


Danio rerio

Features
Gene ID: ENSDARG00000105215
  
Biological name :kdrl
  
Synonyms : kdrl / kinase insert domain receptor like
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 14
Strand: -1
Band:
Gene start: 32983769
Gene end: 33044955
  
Corresponding Affymetrix probe sets: Dr.8039.1.S2_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000134625
NCBI entrez gene - 796537     See in Manteia.
RefSeq - XM_009291142
swissprot - A0A0R4IIR3
ZFIN ID - ZDB-GENE-000705-1
Ensembl - ENSDARG00000105215
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000007646Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kdr / Q5GIT4 / kinase insert domain receptor (a type III receptor tyrosine kinase) / P35968* / kinase insert domain receptor*ENSDARG0000001732141
flt4 / fms-related tyrosine kinase 4 / P35916* / P35917* / Vascular endothelial growth factor receptor 3 *ENSDARG0000010445338
flt1 / fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) / P17948* / fms related tyrosine kinase 1*ENSDARG0000001937138
kita / Q8JFR5 / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog a / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000004331723
pdgfra / platelet-derived growth factor receptor, alpha polypeptide / P26618* / P16234* / platelet derived growth factor receptor alpha* / Mus musculus platelet derived growth factor recept...ENSDARG0000007049423
kitb / v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog b / KIT* / P05532* / P10721* / Mast/stem cell growth factor receptor Kit * / KIT proto-oncogene receptor tyrosine kinase*ENSDARG0000005613322
pdgfrb / platelet-derived growth factor receptor, beta polypeptide / P09619* / platelet derived growth factor receptor beta*ENSDARG0000010089722
csf1ra / colony stimulating factor 1 receptor, a / CSF1R* / P09581* / P07333* / colony stimulating factor 1 receptor* / Macrophage colony-stimulating factor 1 receptor *ENSDARG0000010298621
csf1rb / colony stimulating factor 1 receptor, b / CSF1R* / P07333* / colony stimulating factor 1 receptor*ENSDARG0000005362420
fgfr3 / fibroblast growth factor receptor 3 / P22607*ENSDARG0000000478219
fgfr2 / fibroblast growth factor receptor 2 / P21802* / fibroblast growth factor receptor 2 isoform 3 *ENSDARG0000005811519
fgfr1a / Q90Z00 / fibroblast growth factor receptor 1a / FGFR1* / P11362* / P16092* / fibroblast growth factor receptor 1*ENSDARG0000001102718
fgfr4 / fibroblast growth factor receptor 4 / P22455*ENSDARG0000006910518
flt3 / fms-related tyrosine kinase 3 / P36888*ENSDARG0000005850317
ret / ret proto-oncogene receptor tyrosine kinase / P07949* / P35546* / ret proto-oncogene* / Proto-onco tyrosine-protein kinase receptor Ret Soluble RET kinase fragment Extracellular cell-...ENSDARG0000005530517
fgfr1b / fibroblast growth factor receptor 1b / FGFR1* / P16092* / P11362* / fibroblast growth factor receptor 1*ENSDARG0000001119017


Protein motifs (from Interpro)
Interpro ID Name
 IPR001245  Serine-threonine/tyrosine-protein kinase, catalytic domain
 IPR001824  Tyrosine-protein kinase, receptor class III, conserved site
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008266  Tyrosine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR020635  Tyrosine-protein kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004713 protein tyrosine kinase activity IEA
 molecular_functionGO:0004714 transmembrane receptor protein tyrosine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000014 dorsal aorta dorsal aorta morphology , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart quality , abnormal
Show

 ZFA:0000123 liver liver increased amount , abnormal
liver decreased amount , abnormal
liver vasculature decreased branchiness , abnormal
liver cell fatty , abnormal
liver has extra parts of type ito cell , abnormal
Show

 ZFA:0000477 posterior cardinal vein posterior cardinal vein morphology , abnormal
Show

 ZFA:0001057 intersegmental vein intersegmental vein decreased length , abnormal
intersegmental vein hypoplastic , abnormal
Show

 ZFA:0001061 intersegmental artery intersegmental artery decreased length , abnormal
Show

 ZFA:0001079 blood vasculature blood vasculature quality , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature aplastic , abnormal
cranial vasculature angiogenesis process quality , abnormal
cranial vasculature broken , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel angiogenesis process quality , abnormal
intersegmental vessel aplastic , abnormal
intersegmental vessel morphology , abnormal
intersegmental vessel decreased length , abnormal
intersegmental vessel absent , abnormal
intersegmental vessel decreased size , abnormal
intersegmental vessel decreased amount , abnormal
intersegmental vessel hypoplastic , abnormal
Show

 ZFA:0005002 basilar artery basilar artery absent , abnormal
Show

 ZFA:0005020 central artery central artery absent , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel hypoplastic , abnormal
dorsal longitudinal anastomotic vessel aplastic , abnormal
Show

 ZFA:0009303 endothelial tip cell endothelial tip cell spatial pattern , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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