ENSG00000173511


Homo sapiens

Features
Gene ID: ENSG00000173511
  
Biological name :VEGFB
  
Synonyms : P49765 / vascular endothelial growth factor B / VEGFB
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q13.1
Gene start: 64234538
Gene end: 64238793
  
Corresponding Affymetrix probe sets: 203683_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000311127
Ensembl peptide - ENSP00000401550
Ensembl peptide - ENSP00000442526
NCBI entrez gene - 7423     See in Manteia.
OMIM - 601398
RefSeq - NM_001243733
RefSeq - NM_003377
RefSeq Peptide - NP_001230662
RefSeq Peptide - NP_003368
swissprot - Q7LAP4
swissprot - P49765
swissprot - H0YGB6
Ensembl - ENSG00000173511
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vegfbaENSDARG00000090997Danio rerio
 vegfbbENSDARG00000092480Danio rerio
 VegfbENSMUSG00000024962Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
VEGFA / P15692 / vascular endothelial growth factor AENSG0000011271526
PGF / P49763 / placental growth factorENSG0000011963023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000072  PDGF/VEGF domain
 IPR023581  Platelet-derived growth factor, conserved site
 IPR029034  Cystine-knot cytokine
 IPR036841  Vascular endothelial growth factor, heparin-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IBA
 biological_processGO:0001666 response to hypoxia IBA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IBA
 biological_processGO:0002576 platelet degranulation TAS
 biological_processGO:0006493 protein O-linked glycosylation IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0045766 positive regulation of angiogenesis IBA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IBA
 biological_processGO:0050930 induction of positive chemotaxis IBA
 biological_processGO:0051781 positive regulation of cell division IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060754 positive regulation of mast cell chemotaxis IBA
 biological_processGO:0060976 coronary vasculature development IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031093 platelet alpha granule lumen TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008083 growth factor activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043183 vascular endothelial growth factor receptor 1 binding IBA
 molecular_functionGO:0043184 vascular endothelial growth factor receptor 2 binding IBA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000173511 VEGFB / P49765 / vascular endothelial growth factor B  / complex
 ENSG00000102755 FLT1 / P17948 / fms related tyrosine kinase 1  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr