ENSGALG00000035492


Gallus gallus

Features
Gene ID: ENSGALG00000035492
  
Biological name :ELMO1
  
Synonyms : ELMO1 / engulfment and cell motility 1
  
Possible biological names infered from orthology : Engulfment and cell motility protein 1 / Q8BPU7 / Q92556
  
Species: Gallus gallus
  
Chr. number: 2
Strand: 1
Band:
Gene start: 46514678
Gene end: 46813840
  
Corresponding Affymetrix probe sets: Gga.1661.1.S1_at (Chicken Array)   Gga.1661.2.S1_s_at (Chicken Array)   Gga.1661.3.S1_s_at (Chicken Array)   GgaAffx.20215.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000050717
Ensembl peptide - ENSGALP00000056023
Ensembl peptide - ENSGALP00000043637
NCBI entrez gene - 420735     See in Manteia.
RefSeq - XM_015281546
RefSeq - XM_015281542
RefSeq - XM_015281543
RefSeq - XM_015281544
RefSeq - XM_015281545
RefSeq - NM_001030994
RefSeq - XM_015281536
RefSeq - XM_015281537
RefSeq - XM_015281538
RefSeq - XM_015281539
RefSeq - XM_015281540
RefSeq - XM_015281541
RefSeq Peptide - NP_001026165
swissprot - A0A1D5PSY3
swissprot - A0A1D5PD74
swissprot - Q5ZL97
Ensembl - ENSGALG00000035492
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 elmo1ENSDARG00000098753Danio rerio
 si:dkey-56f14.7ENSDARG00000055400Danio rerio
 ELMO1ENSG00000155849Homo sapiens
 Elmo1ENSMUSG00000041112Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ELMO2 / engulfment and cell motility 2 / Q8BHL5* / Q96JJ3* / Engulfment and cell motility protein 2 *ENSGALG0000000724673
ELMO3 / engulfment and cell motility 3 / Q8BYZ7* / Q96BJ8* / Engulfment and cell motility protein 3 *ENSGALG0000003022056


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR006816  ELMO domain
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR024574  Domain of unknown function DUF3361
 IPR030715  Engulfment and cell motility protein 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006911 phagocytosis, engulfment IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016601 Rac protein signal transduction IEA
 biological_processGO:0030029 actin filament-based process IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0048870 cell motility IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0032045 guanyl-nucleotide exchange factor complex IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0017124 SH3 domain binding IEA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000002656 CRK / Q04929 / Adapter molecule crk / P46108* / Q64010* / CRK proto-oncogene, adaptor protein*  / reaction / complex
 ENSGALG00000003855 SRC / P00523 / Proto-oncogene tyrosine-protein kinase Src / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSGALG00000013907 KDR / vascular endothelial growth factor receptor 2 precursor / P35968* / kinase insert domain receptor*  / reaction / complex
 ENSGALG00000010290 VEGFA / P67964 / Vascular endothelial growth factor A / P15692* / Q00731*  / reaction / complex
 ENSGALG00000015216 SYK / F1N9Y5 / Tyrosine-protein kinase SYK / P48025* / P43405* / spleen tyrosine kinase* / spleen associated tyrosine kinase*  / reaction / complex
 ENSGALG00000042895 BCAR1 / BCAR1, Cas family scaffolding protein / P56945* / Q61140* / Breast cancer anti-estrogen resistance protein 1 *  / complex / reaction
 ENSGALG00000031741 PTK2 / Q00944 / Focal adhesion kinase 1 / P34152* / Q05397* / protein tyrosine kinase 2* / PTK2 protein tyrosine kinase 2*  / complex / reaction
 ENSGALG00000042259 DOCK1 / dedicator of cytokinesis 1 / Q14185* / Q8BUR4* / Dedicator of cytokinesis protein 1 *  / complex
 ENSGALG00000007130 RAC1 / Rac family small GTPase 1 / P63000* / P63001* / RAS-related C3 botulinum substrate 1*  / reaction






 

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